PMID: 9526043Apr 4, 1998Paper

Time-dependent and regional expression of GABA transporter mRNAs following amygdala-kindled seizures in rats

Brain Research. Molecular Brain Research
T HiraoH Suwaki

Abstract

To investigate the role played by GABA transporters in epileptic seizures, we examined time-dependent and regional changes in expression of GAT-1 and GAT-3 GABA transporter mRNA in amygdala-kindled rat brain using an in situ hybridization method. GAT-1 mRNA was significantly increased bilaterally in the hippocampal dentate gyrus (111-116%) at 1 h after kindled generalized seizures. GAT-1 mRNA was also significantly increased bilaterally in the hippocampal subfields (CA1-4 and dentate gyrus [110-117%]) at 4 h after kindled seizures. There were no significant changes in GAT-1 mRNA level in the amygdalar nuclei, pyriform cortex or cerebral cortex either ipsilaterally or contralaterally at any time after kindled seizures. In contrast, GAT-3 mRNA was significantly increased bilaterally in the amygdalar nuclei and in the contralateral pyriform cortex and cerebral cortex 1 h after seizures. Since all these changes returned to control levels by 8 or 24 h after kindled seizures, the increases in GABA transporter mRNA appeared to be transient responses to seizure activity. These findings indicate that GAT-1 subtype transporter is specifically involved in seizure activity in the hippocampus, while GAT-3 subtype transporter is mainly invol...Continue Reading

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Citations

Oct 9, 2001·Brain Research. Molecular Brain Research·M LamasR Gutiérrez
Jun 21, 2001·Neuroreport·C FrahmA Draguhn
May 14, 2014·Epilepsy Research·Mauro DiNuzzoFederico Giove
Dec 13, 2006·Neuroscience Research·Keiko NagatomoNoriko Tsuru
Sep 7, 2004·The Journal of Comparative Neurology·Christiane FrahmOtto W Witte
Mar 10, 2001·Journal of Neuroscience Research·A Gadea, A M López-Colomé
Jan 8, 2018·Pharmacological Reports : PR·Janusz SzyndlerAdam Płaźnik
Jun 25, 2018·Neurochemical Research·Dmitry S VasilevAleksey V Zaitsev
Feb 9, 2021·Experimental Biology and Medicine·Sheila Ms Sears, Sandra J Hewett
Jun 24, 2004·Brain Research. Brain Research Reviews·Fiorenzo ContiMarcello Melone

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