Time-dependent associations between presentation-based infections and subsequent risk of childhood immune cell malignancies.

Cancer Epidemiology
TienYu Owen YangWan-Ting Huang

Abstract

Infection is hypothesised as a contributory cause of childhood immune cell malignancies. Although some have reported associations between individual infections and immune cell malignancies, some could be spurious due to infections caused by malignancies that were already active prior to diagnosis. Identified from Taiwan Cancer Registry, ∼3000 children with four commonest immune cell malignancies diagnosed during 2001-2015 at age 1-20 years were identified and matched with 1:10 controls. Using logistic regression, we estimated the time-specific case-versus-control odds ratios of seven common infection presentations in their health records. We also compared recorded unexplained lymph nodes between cases and controls to explore for how long malignancy may be active prior to diagnosis. Unexplained lymph nodes were increasingly recorded months before the diagnosis of childhood leukaemias and years before the diagnosis of childhood lymphomas. When using p < 0.01 as a guide, large case-control differences in infection records were found mostly within 0-2 months prior to the diagnosis (15 out of 28 comparisons). Changes in odds ratios within 3-35 months (2 out of 28 comparisons) and case-control differences beyond 36+ months prior to d...Continue Reading

References

Feb 16, 2005·Cancer·Eva Steliarova-FoucherPeter Kaatsch
Feb 10, 2006·Nature Reviews. Cancer·Mel Greaves
Nov 11, 2010·British Journal of Cancer·L Kinlen
Jul 28, 2012·International Journal of Epidemiology·Jeffrey S ChangJoseph L Wiemels
Aug 24, 2012·Pediatric Blood & Cancer·Therese Risom VestergaardHenrik Hjalgrim
May 6, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Erin L MarcotteJulia E Heck
Oct 16, 2014·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·TienYu Owen YangPau-Chung Chen
Jan 21, 2015·Cancer Epidemiology·Yen-Lin LiuMei-Shu Lai
Jan 21, 2015·Japanese Journal of Clinical Oncology·Chun-Ju ChiangMei-Shu Lai
Apr 30, 2016·Pediatric Blood & Cancer·TienYu Owen YangPau-Chung Chen
Apr 30, 2019·The Pediatric Infectious Disease Journal·TienYu Owen YangWan-Ting Huang

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