Time-dependent cardiovascular and inflammatory changes in acute endotoxemia

Shock
K YinP Y Wong

Abstract

The pathophysiology of experimental acute endotoxemia is a complex process involving both cardiovascular dysfunction and an inflammatory response. We have examined the correlation in hemodynamic changes and the pulmonary inflammatory response after lipopolysaccharide (LPS) administration with respect to time. Importantly, we have measured the lung and plasma levels of nitric oxide (NO) over time, as well as rapid generation of lung superoxide after LPS administration. In anesthetized rats given a bolus injection of LPS (10 mg/kg intravenously, from Salmonella enteritidis), mean arterial blood pressure dropped by 63-70% within 15 min, and cardiac output fell by 57-63% within 20 min compared with saline controls. Mean arterial blood pressure recovered slightly but was still 51, 30, and 25% less than that of saline controls 45, 105, and 165 min after LPS administration, respectively. Cardiac output remained depressed throughout the experimental period and was 35% lower than in saline controls 165 min after LPS treatment. There was a small increase in plasma nitrite/nitrate as an index of plasma NO production after 45 min and a 10-fold increase 165 min after LPS addition compared with controls, strongly suggesting that NO mediates ...Continue Reading

Citations

Aug 19, 2003·British Journal of Pharmacology·Andrew MacKenzie, Roger M Wadsworth
Nov 23, 2006·The Journal of Surgical Research·Kingsley YinManucher Fallahnejad
Jun 1, 2001·Nitric Oxide : Biology and Chemistry·D MailmanF Murad
Sep 24, 2005·Molecular and Cellular Biochemistry·Ramasamy P PandianPeriannan Kuppusamy

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