Time-dependent changes in GLT-1 functioning in striatum of hemi-Parkinson rats

Neurochemistry International
Ann MassieYvette Michotte

Abstract

Striatal dopamine loss in Parkinson's disease is accompanied by a dysregulation of corticostriatal glutamatergic neurotransmission. Within this study, we investigated striatal expression and activity of the glial high-affinity Na(+)/K(+)-dependent glutamate transporters, GLT-1 and GLAST, in the 6-hydroxydopamine hemi-Parkinson rat model at different time points after unilateral 6-hydroxydopamine injection into the medial forebrain bundle. Using semi-quantitative Western blotting and an ex vivo D-[(3)H]-aspartate uptake assay, we showed a time-dependent bilateral effect of unilateral 6-hydroxydopamine lesioning on the expression as well as activity of GLT-1. At 3 and 12 weeks post-lesion, striatal GLT-1 function was bilaterally upregulated whereas at 5 weeks there was no change. Even though our data do not allow a straightforward conclusion as for the role of glutamate transporters in the pathogenesis of the disease, they do clearly demonstrate a link between disturbed glutamatergic neurotransmission and glutamate transporter functioning in the striatum of a rat model for Parkinson's disease.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T StorckW Stoffel
Nov 1, 1992·Journal of Neurobiology·D W Choi
Mar 10, 1981·Neuroscience Letters·B Fass, L L Butcher
Feb 1, 1993·Neuroscience Research·K Tanaka
Jun 1, 1996·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·P AngladeE Hirsch
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·J L ArrizaS G Amara
May 23, 2001·Progress in Neurobiology·N C Danbolt
Feb 26, 2003·European Journal of Pharmacology·Claudia CorsiFelicita Pedata
Jan 29, 2005·The Journal of Comparative Neurology·Maria CastleJosé L Lanciego
May 23, 2007·Neurochemistry International·Amanda L Sheldon, Michael B Robinson
Sep 5, 2008·The Journal of Comparative Neurology·Ann MassieYvette Michotte
May 11, 2010·Neurochemistry International·Ann MassieYvette Michotte

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Citations

Nov 19, 2013·Pflügers Archiv : European journal of physiology·Christof GrewerThomas Rauen
Mar 30, 2012·Neurogenetics·Leslie C JellenByron C Jones
Oct 15, 2014·Pharmacology, Biochemistry, and Behavior·Neha SoniPuneet Kumar
Jun 23, 2015·Journal of Neurochemistry·Andréia C K Fontana
Sep 24, 2015·Pharmacological Reports : PR·Karita RaudkiviJaanus Harro
Sep 9, 2015·Neural Plasticity·Giselle CheungNathalie Rouach
Jun 20, 2015·Neural Plasticity·Cristiane BatassiniCarlos-Alberto Gonçalves
Jan 13, 2015·Nature Neuroscience·Ciaran Murphy-RoyalStéphane H R Oliet
Jun 21, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Tanya ChotibutMichael F Salvatore
Jul 7, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stéphanie GoursaudEmmanuel Hermans
Jun 7, 2013·Expert Review of Neurotherapeutics·Linda MacArthurHoward J Federoff
Apr 12, 2019·Frontiers in Neuroscience·Ebrahim M YimerKald Beshir Tuem
Dec 11, 2020·Cells·Ikuko Miyazaki, Masato Asanuma
May 23, 2020·Neurochemistry International·Luan Pereira DinizFlávia Carvalho Alcantara Gomes

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