Time-dependent changes of oxime K027 concentrations in different parts of rat central nervous system.

Neurotoxicity Research
Jana KarasovaKamil Kuca

Abstract

The blood-brain barrier plays a vital role in the protection of the central nervous system. It is composed of endothelial cells with tight-junctions to limit the penetration of many endogenous and exogenous compounds, particularly hydrophilic xenobiotics. Nerve agents and pesticides are groups of compounds with high penetration potential into the central nervous system. However, oxime type antidotes are known to penetrate blood-brain barrier only in low concentration. The aim of presented study is to describe the pharmacokinetic profile of oxime K027 a novel antidote candidate. The main focus is on penetration of tested substance into the selected brain regions following time-dependent manner. The maximum concentration of the oxime K027 was attaining 15 and 30 min after i.m. application in plasma and brain tissue, respectively. The perfused brain tissue concentration was relatively high (10(-7) M order of magnitude) and depending on the brain region it was constant 15-60 min after application. The highest concentration was found in the frontal cortex 15 min after application while the lowest measured concentration was determined in the basal ganglia. This study showed that oxime K027 is able to achieve high concentration level ...Continue Reading

References

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Citations

Apr 1, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Martin MzikJana Zdarova Karasova
Oct 8, 2014·Journal of Applied Toxicology : JAT·H KalászK Tekes
Sep 5, 2014·Journal of Applied Toxicology : JAT·Georg A PetroianuDietrich E Lorke
Feb 1, 2021·Archives of Toxicology·Lukas GoreckiJan Korabecny
Oct 30, 2020·International Journal of Molecular Sciences·Jana Zdarova KarasovaVit Sestak

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