Time-dependent cytokine deviation toward the Th2 side in Japanese multiple sclerosis patients with interferon beta-1b

Journal of the Neurological Sciences
Hirofumi OchiJ Kira

Abstract

To address the immune mechanism sustaining interferon beta (IFNbeta) efficacy in multiple sclerosis (MS), we longitudinally analyzed expressions of IFN-gamma, IL-4, IL-5 and IL-13 in CD4+ T cells and CD8+ T cells in 22 Japanese MS patients (16 patients with conventional MS and 6 with opticospinal MS) undergoing IFNbeta using flow cytometry. During the 48-week observation period, five opticospinal MS patients (83%) relapsed compared to only four conventional MS patients (25%); the frequency of relapsed patients was significantly higher in the former (p=0.046). The effects of IFNbeta on individual cytokines were time-dependent and altered cytokine productions were particularly evident in CD4+ rather than CD8+ T cells. A decreased intracellular IFN-gamma/IL-4 ratio in CD4+ T cells was thus evident soon after the initiation of therapy, and persisted for the entire 1 year follow-up period, regardless of whether or not the patient relapsed (p<0.01). IFNbeta treatment resulted in a rapid increase in the percentage of IFN-gamma- IL-4+ and IL-13+ CD4+ T cells 1 week after the initiation of therapy and high values were sustained for 6 months but declined to the baseline over 1 year. Later, the percentage of IFN-gamma+ IL-4- CD4+ T cells ...Continue Reading

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Citations

Nov 26, 2009·Rinshō shinkeigaku = Clinical neurology·Jun-ichi Kira
Jun 6, 2008·Neurochemistry International·Johann SellnerHeinrich P Mattle
Feb 24, 2015·Cytokine·Dusanka S SkundricHarley Y Tse
Jul 16, 2014·The International Journal of Neuroscience·Belgin Petek-BalcıMefküre Eraksoy
May 26, 2009·Multiple Sclerosis : Clinical and Laboratory Research·T MatsushitaJ I Kira
May 4, 2007·Endocrine Reviews·Mario RotondiPaola Romagnani
Jul 20, 2019·The British Journal of Dermatology·E PetersonA G Franks

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