Time-dependent differential changes of immune function in rats exposed to chronic intermittent noise

Physiology & Behavior
M T Van RaaijH Van Loveren

Abstract

Noise is a highly relevant environmental and clinical stressor. Compared to most other experimental stressors, noise is a modest activator of neuroendocrine pathways that mimic the situation in human health where neuroendocrine activation by environmental stressors is often absent or difficult to establish. Little is known about the effects of noise exposure on the immune system. In the present work, the effects of a low-intensity chronic intermittent unpredictable noise regimen on various parameters of immune function was studied. Male wistar rats were exposed to a randomized noise protocol (white noise, 85 dB, 2-20 kHz) for 10 h per day, 15 min per h over a total period of 3 weeks. Control animals were exposed to ambient sound only. Immune function was monitored after 24 h, 7 days, and 21 days of noise exposure. Noise induced several significant changes in immune function in a time-dependent differential pattern involving both immunosuppression and immunoenhancement. After 24 h, serum IgM levels were increased and peripheral phagocytic activity was decreased. Splenic lymphocytic proliferation to mitogens was significantly decreased after 7 days, but slightly elevated after 3 weeks. The activity of splenic NK cells was increas...Continue Reading

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Citations

Apr 10, 2013·Cellular and Molecular Neurobiology·Daniela CalziaIsabella Panfoli
Sep 3, 2010·Cell Biochemistry and Biophysics·Silvia RaveraAlessandro Morelli
Feb 23, 2007·Journal of Occupational Health·Kui-Cheng Zheng, Makoto Ariizumi
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Jul 1, 2020·ILAR Journal·Randall ReynoldsJohn Norton
May 14, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Amirreza Abouee-MehriziMehran Mesgari-Abbasi
Mar 9, 2021·Frontiers in Immunology·Andi ZhangMingliang Xiang

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