Time-dependent effect of isradipine on the nocturnal hypertension in chronic renal failure

American Journal of Hypertension
F PortaluppiC Fersini

Abstract

Nocturnal hypertension is frequently observed in chronic renal failure and contributes to the risk of target organ damages. We assessed whether antihypertensive therapy may restore a nocturnal blood pressure (BP) fall in this condition. A sustained-release oral formulation (SRO) of isradipine was used, and the possible differences in the response to morning nu evening dosing were also investigated. Sixteen hypertensive patients with chronic renal failure due to parenchymal kidney disease were studied after 2 weeks of single-blind placebo runin. According to the double-blind, randomized, cross-over design, they received 5 mg isradipine SRO at 08:00, or at 20:00 for 4 weeks, separated by a single-blind placebo period of 2 weeks. A 24-h BP monitoring at 10-min intervals was carried out at the end of each treatment using a SpaceLabs 90207 instrument. Under placebo, blunt BP profiles were observed, whereas HR showed a mean nocturnal fall of 17.4%, which remained unaltered after isradipine. Both isradipine treatments were equally effective in reducing the mean 24-h BP levels. However, the evening regimen showed a more pronounced effect during the night. The mean nocturnal fall in systolic/diastolic BP represented 4.8/8.7% and 7.5/10....Continue Reading

Citations

Aug 15, 1996·Annals of the New York Academy of Sciences·B Lemmer
Aug 15, 1996·Annals of the New York Academy of Sciences·T Rosenthal
Aug 15, 1996·Annals of the New York Academy of Sciences·M Middeke
Aug 15, 2009·Journal of Applied Physiology·R Daniel Rudic, David J Fulton
Mar 25, 2008·Therapeutics and Clinical Risk Management·Ramón C HermidaCarlos Calvo
Jan 14, 2012·Vascular Health and Risk Management·John M Flack, Samar A Nasser
Sep 21, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ran-Hui ChaYon Su Kim
Nov 22, 2005·Expert Opinion on Drug Delivery·Björn Lemmer
Mar 24, 2005·The Journal of Clinical Hypertension·Thomas G Pickering
Oct 20, 2012·Chronobiology International·Ramón C HermidaFrancesco Portaluppi
Jul 5, 2008·American Journal of Hypertension·Ramón C HermidaJosé R Fernández
Sep 30, 2008·International Journal of Clinical Practice·L-L ZhuS Zeng
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mahboob Rahman, Lawrence J Appel
Nov 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Roberto MinutoloLuca De Nicola
Aug 7, 2007·Advanced Drug Delivery Reviews·Francesco Portaluppi, Björn Lemmer
May 11, 2007·Expert Review of Cardiovascular Therapy·Björn Lemmer
May 11, 2007·Expert Review of Cardiovascular Therapy·Ramón C HermidaFrancesco Portaluppi
Sep 9, 2005·Chronobiology International·Ramón C HermidaJosé R Fernández
Dec 18, 2014·The Annals of Pharmacotherapy·Paul M StrangesAmie D Brooks
Aug 10, 2004·Current Opinion in Nephrology and Hypertension·Ramón C Hermida, Michael H Smolensky
Aug 13, 2003·Circulation·Ramon C HermidaManuel Covelo
Apr 7, 2007·Journal of Cardiovascular Pharmacology·Mahmoud M El-Mas, Abdel A Abdel-Rahman
Jul 14, 2009·Current Opinion in Nephrology and Hypertension·Puja GoswamiMahboob Rahman
Aug 29, 2009·Current Opinion in Nephrology and Hypertension·Rajiv Agarwal
Jan 12, 2010·Pharmacy World & Science : PWS·Arwa Hassan, Walter E Haefeli
Jul 28, 2005·Current Opinion in Nephrology and Hypertension·Ramón C HermidaCarlos Calvo
Sep 9, 2005·Journal of Hypertension·Ramón C HermidaJosé E López
Jun 10, 2009·Expert Review of Cardiovascular Therapy·Rajiv Vij, Aldo J Peixoto
Jul 29, 2009·Chronobiology International·Jose Cabezas-CerratoDiana Elva Ayala
Feb 6, 2009·Blood Pressure Monitoring·Rajiv AgarwalCarmine Zoccali
Feb 24, 2001·Journal of Hypertension·C ZoccaliF Tassone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.