Time-dependent effect of phytocannabinoid treatments in fat cells

Phytotherapy Research : PTR
S RamlugonC L Frost

Abstract

The objectives of this paper is to investigate, demonstrate, and compare the mechanism of action of phytocannabinoids as antidiabetic and anti-obesity agents in preadipocytes and adipocytes, relative to rosiglitazone and metformin. Briefly, cannabis extract, Δ9 -tetrahydrocannabinol and cannabidiol (in very low dosages) were shown to promote glucose uptake higher or to equivalent levels, reduce fat accumulation, and reverse the insulin-resistant state of 3T3-L1 cells more effectively, relative to rosiglitazone and metformin. The phytocannabinoids had a more pronounced effect in preadipocytes undifferentiated model rather than the differentiated model. They induced a protective effect at the mitochondrial level by preventing overactivity of the succinate dehydrogenase pathway (p < .01), unlike rosiglitazone, through activation of the glycerol-3-phosphate dehydrogenase shuttling system. An increase in oxygen consumption and an increased expression of beta to alpha adrenoceptors (p < .05) in treated cells were noted. These findings contribute toward understanding the mechanism of action of phytocannabinoids in fat cells and highlight the antidiabetic and anti-obesity properties of various phytocannabinoids that could potentially s...Continue Reading

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Citations

Jun 11, 2019·Phytotherapy Research : PTR·Angelo A Izzo
Mar 21, 2020·Frontiers in Endocrinology·Patrycja BielawiecAdrian Chabowski
Sep 15, 2020·Cannabis and Cannabinoid Research·Tal Assa-GlazerZecharia Madar
Nov 27, 2020·Journal of Ethnopharmacology·F Odei-AddoC L Frost
Mar 25, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·François-Xavier GamelinElsa Heyman

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