Time-dependent effects of a high-energy-yielding diet on the regulation of specific white adipose tissue genes

Biochemical and Biophysical Research Communications
J MargaretoJ A Martínez

Abstract

White adipose tissue development is regulated by many factors, including the energy content of food and the genetic background. Nevertheless, little is known about possible differential effects of high-fat palatable diets when fed for short or long-time periods. Thus, the expression of certain genes involved with lipid metabolism (peroxisome proliferator-activated receptor gamma, PPARgamma2; retinoic receptors; fatty acid binding protein, aP2 and uncoupling proteins, UCP) may be affected by those dietary manipulations (high-energy-yielding diet and time duration of feeding). High-fat feeding for 8 days decreased mRNA UCP3 levels compared to control fed animals, while feeding for 30 days increased them over controls. Similar findings occurred for PPARgamma2 and aP2. Furthermore, statistically significant associations were found among PPARgamma2, aP2 and UCP3 mRNA levels. These data suggest a physiological time-dependent response seeking to prevent excessive fat deposition when animals are fed for short-term with a high amount of dietary fat, which was followed by an adaptive period to the high-energy content of diet throughout a coregulation among certain lipid metabolism related genes: PPARgamma2, aP2, UCP3.

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Citations

Mar 9, 2002·Biochemical and Biophysical Research Communications·María J Moreno-AliagaJ Alfredo Martínez
Nov 19, 2002·Journal of Physiology and Biochemistry·A MartiJ A Martínez
Jan 22, 2002·Journal of Physiology and Biochemistry·J A MartínezM J Moreno Aliaga
Oct 16, 2004·Obesity Research·Enrique RodríguezAndreu Palou
Apr 28, 2004·Biochemical and Biophysical Research Communications·I P LópezC De Miguel
Apr 10, 2003·Biochemical and Biophysical Research Communications·Mary Anne Della-FeraClifton A Baile
May 7, 2008·Journal of Physiology and Biochemistry·N Pérez-EcharriM J Moreno-Aliaga
Mar 14, 2002·Current Opinion in Lipidology·Jeffrey B BoordMacRae F Linton
Dec 13, 2005·Molecular and Cellular Biochemistry·I P LopezC De Miguel
Mar 20, 2003·Journal of Animal Science·S T DingH J Mersmann

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