PMID: 9194146May 1, 1997Paper

Time-dependent effects of fructose on the modulation of a reactivated memory

Progress in Neuro-psychopharmacology & Biological Psychiatry
C A HorneJ L Padilla

Abstract

1. A passive-avoidance-to-active-avoidance negative transfer paradigm was used to investigate systematically the time-dependent effects of fructose on reactivated memories in rats. 2. Memory reactivation consisted of re-exposing the rats 24 hr after passive-avoidance conditioning to environmental and learning cues present during training; post-reactivation injections of fructose (100 mg/kg, sc) or saline were followed 24 hr later by active-avoidance (discrimination reversal) conditioning. Fructose or saline was administered in the experimental room 0, 2, 5, or 30 min, or in the colony room 60 min, after reactivation. 3. The results showed a time-dependent decrease in the ability of fructose to modulate a reactivated memory. 4. These results suggest that the time-dependent effects for the modulation of a reactivated memory by fructose (a hexose that does not readily pass the blood-brain barrier) and glucose (a hexose that readily passes the blood-brain barrier) follow similar trends.

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Citations

Dec 17, 2008·Neurotoxicity Research·Lia R BevilaquaMartín Cammarota
Jan 22, 2003·Trends in Neurosciences·Karim Nader
Dec 3, 1999·Progress in Neuro-psychopharmacology & Biological Psychiatry·W A RodriguezJ L Padilla
Feb 21, 2009·Nature Reviews. Neuroscience·Karim Nader, Oliver Hardt
Aug 3, 2006·Learning & Memory·Janine I RossatoMartín Cammarota
Aug 15, 2007·Pakistan Journal of Biological Sciences : PJBS·A A MoazediG H Parham
Aug 9, 2007·Brain Research Bulletin·Carles Soriano-MasPilar Segura-Torres
Dec 26, 2001·Neurobiology of Learning and Memory·Catherine J LawsonAlan J Taylor
Jan 16, 1999·Neurobiology of Learning and Memory·C P TalleyP E Gold
Nov 21, 2017·European Journal of Psychotraumatology·Muriel A HagenaarsBernet Elzinga
Dec 12, 2020·Neurobiology of Learning and Memory·M C KrawczykM M Boccia

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