Time-dependent increase in plasma prolactin after pituitary stalk section: role of posterior pituitary dopamine

Endocrinology
I MuraiN Ben-Jonathan

Abstract

PRL secretion is inhibited by dopamine (DA) input from two systems: the tuberoinfundibular (TIDA) with terminals in the median eminence, and the tuberohypophyseal (THDA) with terminals in the posterior pituitary. The aims of this study were 1) to determine the effects of pituitary stalk section (SS), which prevents DA input from the TIDA neurons, on PRL release, and 2) to assess if the anterior pituitary receives any DA input after SS. Ovariectomized rats were subjected to SS or sham surgery. Jugular blood was collected on the day of surgery (day 0) and for 6 days thereafter and was analyzed for PRL by RIA. DA concentration in the posterior pituitary was determined by HPLC. Unexpectedly, SS caused only a 2- to 3-fold initial rise in plasma PRL on day 0. This was followed by a gradual rise to 4-, 6-, and 8-fold above control levels on days 2, 4, and 6, respectively, without a further increase by 2 weeks. During this time, DA concentrations in the posterior pituitary progressively declined to 66%, 28%, and 6% of control values on days 1, 2, and 6 after SS, respectively. In the second experiment, intact and SS rats were treated with the DA receptor antagonist haloperidol. Haloperidol induced a dramatic 30- to 40-fold increase in p...Continue Reading

Citations

Jan 1, 1989·Progress in Neurobiology·N Ben-JonathanJ F Hyde
Aug 1, 1994·Neuroscience Letters·R J BaldessariniJ L Neumeyer
Nov 20, 1998·Animal Reproduction Science·S J ChoL L Anderson
Jan 1, 1992·Journal of Cognitive Neuroscience·M LucianaA Leon
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Feb 20, 2014·Journal of Neuro-oncology·Marvin BergsneiderAnthony P Heaney

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