Time-Dependent Predictors of Loss to Follow-Up in a Large HIV Treatment Cohort in Nigeria

Open Forum Infectious Diseases
Seema Thakore MeloniPhyllis Kanki

Abstract

Most evaluations of loss to follow-up (LTFU) in human immunodeficiency virus (HIV) treatment programs focus on baseline predictors, prior to antiretroviral therapy (ART) initiation. As risk of LTFU is a continuous issue, the aim of this evaluation was to augment existing information with further examination of time-dependent predictors of loss. This was a retrospective evaluation of data collected between 2004 and 2012 by the Harvard School of Public Health and the AIDS Prevention Initiative in Nigeria as part of PEPFAR-funded program in Nigeria. We used multivariate modeling methods to examine associations between CD4(+) cell counts, viral load, and early adherence patterns with LTFU, defined as no refills collected for at least 2 months since the last scheduled appointment. Of 51 953 patients initiated on ART between 2004 and 2011, 14 626 (28%) were LTFU by 2012. Factors associated with increased risk for LTFU were young age, having nonincome-generating occupations or no education, being unmarried, World Health Organization (WHO) stage, having a detectable viral load, and lower CD4(+) cell counts. In a subset analysis, adherence patterns during the first 3 months of ART were associated with risk of LTFU by month 12. In settin...Continue Reading

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Citations

Dec 20, 2017·Open Forum Infectious Diseases·Seema T MeloniPhyllis J Kanki
Apr 14, 2019·HIV Medicine·A JiamsakulUNKNOWN TREAT Asia HIV Observational Database of IeDEA Asia-Pacific
Sep 10, 2016·Epidemiology and Infection·R R LilianR P H Peters
Feb 7, 2020·Journal of the International Association of Providers of AIDS Care·Juliet AdeolaPatricia Agaba
Aug 14, 2019·AIDS Research and Therapy·Babatunde AdelekanAhmad Aliyu
Dec 6, 2019·Frontiers in Public Health·Zvifadzo Matsena ZingoniEustasius Musenge
Mar 3, 2018·Open Forum Infectious Diseases·Patricia A AgabaPhyllis J Kanki
Mar 5, 2020·Journal of the International AIDS Society·Aneth V KalinjumaUNKNOWN KIULARCO Study Group

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