Time-dependent reactive species formation and oxidative stress damage in the skin after UVB irradiation

Journal of Photochemistry and Photobiology. B, Biology
V A TerraA L Cecchini

Abstract

This study provides evidence that skin oxidative stress injury caused by UVB irradiation is mediated predominantly by reactive oxygen species immediately after irradiation and by reactive nitrogen species at later time points. Animals were pre-treated with free radical scavengers (deferrioxamine, histidine), α-tocopherol, or inhibitors of nitric oxide synthase (NOS) (L-NAME or aminoguanidine) or left untreated and subjected to UVB irradiation. α-Tocopherol inhibited the increase in lipid peroxidation, as evaluated by chemiluminescence at 0 h and 24 h after UVB irradiation. Immediately after UVB irradiation, lipid peroxidation increased moderately and was abolished by free radical scavengers but not by NOS inhibitors. Likewise, the reduction of antioxidant capacity was not reversed by NOS inhibitors. Nitric oxide augmentation was not observed at this time point. Twenty-four hours after irradiation, increased lipid peroxidation levels and nitric oxide elevation were observed and were prevented by NOS inhibitors. Low concentrations of GSH and reduced catalase activity were also observed. Altogether, these data indicate that reactive oxygen species (singlet oxygen and hydroxyl radicals) are the principal mediators of immediate dama...Continue Reading

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Citations

Apr 1, 2014·Journal of Photochemistry and Photobiology. B, Biology·Mariane Arnoldi SilvaJuliano Ferreira
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Oct 2, 2020·Pathology, Research and Practice·Gabriella Pasqual-MeloAlessandra L Cecchini

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