Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure

American Journal of Physiology. Heart and Circulatory Physiology
Hiroshi AshikagaJ W Covell

Abstract

To test the hypothesis that the abnormal ventricular geometry in failing hearts may be accounted for by regionally selective remodeling of myocardial laminae or sheets, we investigated remodeling of the transmural architecture in chronic volume overload induced by an aortocaval shunt. We determined three-dimensional finite deformation at apical and basal sites in left ventricular anterior wall of six dogs with the use of biplane cineradiography of implanted markers. Myocardial strains at end diastole were measured at a failing state referred to control to describe remodeling of myofibers and sheet structures over time. After 9 +/- 2 wk (means +/- SE) of volume overload, the myocardial volume within the marker sets increased by >20%. At 2 wk, the basal site had myofiber elongation (0.099 +/- 0.030; P <0.05), whereas the apical site did not [P=not significant (NS)]. Sheet shear at the basal site increased progressively toward the final study (0.040 +/- 0.003 at 2 wk and 0.054 +/- 0.021 at final; both P <0.05), which contributed to a significant increase in wall thickness at the final study (0.181 +/- 0.047; P < 0.05), whereas the apical site did not (P=NS). We conclude that the remodeling of the transmural architecture is regiona...Continue Reading

References

Oct 1, 1990·Circulation·K T WeberP W Armstrong
Jul 1, 1973·Journal of Applied Physiology·C YoranJ Ross
Aug 1, 1974·Journal of Molecular and Cellular Cardiology·H M SpotnitzE H Sonnenblick
Mar 1, 1969·Circulation Research·D D StreeterE H Sonnenblick
Jun 1, 1980·IEEE Transactions on Bio-medical Engineering·G D MeierA A Bove
Dec 1, 1994·The American Journal of Physiology·Y ChenR J Tomanek
May 1, 1995·The American Journal of Physiology·I J LeGriceJ W Covell
Feb 10, 1999·The American Journal of Physiology·K D CostaJ W Covell
Aug 18, 2000·Cardiovascular Research·R MazhariA D McCulloch
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S M DolgilevichC Eng
Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Yasuo TakayamaJames W Covell
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Gregory L BrowerJoseph S Janicki
Jan 30, 2003·Journal of Cardiac Failure·A Martin Gerdes
Feb 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Keith L HerrmannJeffrey H Omens
Oct 11, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi AshikagaNeil B Ingels
Nov 5, 2003·Current Opinion in Cardiology·David JoyceGuillermo Torre-Amione
Jan 31, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi AshikagaJames W Covell

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Citations

Feb 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Hiroshi AshikagaJeffrey H Omens
Apr 24, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hiroshi AshikagaHenry R Halperin
Feb 18, 2010·Drug Discovery Today. Disease Models·B A Coppola, J H Omens
Oct 2, 2007·The Journal of Thoracic and Cardiovascular Surgery·Randolph M SetserRichard D White
Feb 22, 2012·IEEE Transactions on Bio-medical Engineering·Hiroshi Ashikaga, Jeffrey H Omens
Dec 26, 2007·The American Journal of Cardiology·Florence H SheehanAlan H Stolpen
Apr 8, 2015·PLoS Computational Biology·Nancy K DrewAnna Grosberg
Dec 13, 2005·Circulation Research·Patrick A HelmRaimond L Winslow
Aug 13, 2008·Circulation·James W Covell
Apr 8, 2006·Current Opinion in Cardiology·Dirk L Brutsaert, Gilles W De Keulenaer
Nov 4, 2020·Journal of Cardiovascular Development and Disease·Peter Agger, Robert S Stephenson
Jun 6, 2021·Scientific Reports·Yukinobu ItoAkiteru Goto

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