PMID: 11342970May 9, 2001Paper

Time dependent smooth muscle regeneration and maturation in a bladder acellular matrix graft: histological studies and in vivo functional evaluation

The Journal of Urology
J WeferE A Tanagho

Abstract

We evaluated the time dependence of smooth muscle regeneration and restoration of in vivo functional properties in bladder augmented with a bladder acellular matrix graft. A total of 45 Sprague-Dawley rats underwent augmentation cystoplasty with a bladder acellular matrix graft. Two rats each were sacrificed at various intervals within the first 21 days and 6 each were sacrificed at 4, 8 and 12 weeks. This second group underwent preoperative and postoperative assessment of bladder function, including cystometry, electrostimulation and stimulation with ice water, potassium and carbachol, as well as labeling of the bladder wall by the injection of fluorescent microspheres. After sacrifice slides of the bladders prepared for hematoxylin and eosin, trichrome, KI67, vimentin, desmin, smooth muscle specific alpha-actin and fluorescent microspheres were evaluated. Within 2 weeks the number of cells in the matrix as well as the proliferation index increased rapidly and then decreased gradually. Erythrocytes and inflammatory cells were found in the matrix within 2 to 4 days, followed by fibroblasts. A bladder host-to-matrix shift was evident by the appearance of microspheres in the matrix. Cell marker expression indicated the early appe...Continue Reading

References

Apr 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·D W ThomasJ P Shepherd
Aug 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J D MahanS A Koff
Oct 1, 1995·Paraplegia·P MastK Everaert
Apr 1, 1997·British Journal of Urology·M ProbstE A Tanagho
Apr 18, 1997·International Journal of Cardiology·U BrinckT Meyer
Aug 8, 1998·Journal of the Autonomic Nervous System·M OikeY Ito
Oct 17, 1998·World Journal of Urology·C R Chapple, N P Bryan
Dec 16, 1998·International Urogynecology Journal and Pelvic Floor Dysfunction·K M Kashif, S A Holmes
Mar 19, 1999·The Journal of Urology·R D Mills, U E Studer
Aug 24, 1999·The Journal of Urology·H Y WuG R Cunha

❮ Previous
Next ❯

Citations

Feb 14, 2006·World Journal of Urology·Karl-Dietrich SievertEmil A Tanagho
Mar 22, 2003·Current Urology Reports·Adam R MetwalliBradley P Kropp
Feb 18, 2011·British Medical Bulletin·Anthony Atala
Feb 15, 2012·Annals of Surgery·Giuseppe OrlandoShay Soker
Jul 31, 2013·Tissue Engineering. Part B, Reviews·Lujie SongAnthony Atala
Jan 24, 2016·Current Urology Reports·Bryan S SackCarlos R Estrada
Nov 17, 2011·International Neurourology Journal·James J YooBupwan Kim
Sep 17, 2004·The Journal of Urology·Bradley P KroppYuanyuan Zhang
Dec 3, 2014·Advanced Drug Delivery Reviews·Joshua R Mauney, Rosalyn M Adam
Sep 22, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Sean Vincent Murphy, Anthony Atala
Sep 7, 2012·International Braz J Urol : Official Journal of the Brazilian Society of Urology·André Luís Alonso DomingosSilvio Tucci Junior
May 5, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Andre L A DomingosAntonio C P Martins
Jul 5, 2005·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Richard A Santucci, Theodore D Barber
Apr 25, 2008·Scandinavian Journal of Urology and Nephrology·Hans FrederiksenBengt Uvelius
Apr 29, 2014·The Journal of Urology·Marije SloffWout Feitz
May 24, 2007·Tissue Engineering·Kazuyoshi IijimaOsamu Nishizawa
Dec 29, 2006·Urologia Internationalis·Bernhard BrehmerGerhard Jakse
Jan 24, 2014·TheScientificWorldJournal·Hazem OrabiStéphane Bolduc
May 2, 2013·Biomedizinische Technik. Biomedical Engineering·Xuemei FanHuicheng Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.