PMID: 8962129Dec 10, 1996Paper

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

Proceedings of the National Academy of Sciences of the United States of America
F YuanR K Jain

Abstract

The hyperpermeability of tumor vessels to macromolecules, compared with normal vessels, is presumably due to vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) released by neoplastic and/or host cells. In addition, VEGF/VPF is a potent angiogenic factor. Removal of this growth factor may reduce the permeability and inhibit tumor angiogenesis. To test these hypotheses, we transplanted a human glioblastoma (U87), a human colon adenocarcinoma (LS174T), and a human melanoma (P-MEL) into two locations in immunodeficient mice: the cranial window and the dorsal skinfold chamber. The mice bearing vascularized tumors were treated with a bolus (0.2 ml) of either a neutralizing antibody (A4.6.1) (492 micrograms/ml) against VEGF/VPF or PBS (control). We found that tumor vascular permeability to albumin in antibody-treated groups was lower than in the matched controls and that the effect of the antibody was time-dependent and influenced by the mode of injection. Tumor vascular permeability did not respond to i.p. injection of the antibody until 4 days posttreatment. However, the permeability was reduced within 6 h after i.v. injection of the same amount of antibody. In addition to the reduction in vascular permeabili...Continue Reading

References

Oct 1, 1977·Radiology·L E GerweckS Sweigert
Sep 1, 1992·The Journal of Cell Biology·M G LampugnaniE Dejana
May 1, 1986·Microvascular Research·L E Gerlowski, R K Jain
Oct 15, 1988·Cancer·D Kritchevsky
Jan 1, 1987·Cancer Metastasis Reviews·R K Jain
Mar 27, 1995·Annals of the New York Academy of Sciences·N FerraraG R Thomas
Jan 2, 1993·International Journal of Cancer. Journal International Du Cancer·M Cordier-BussatG M Lenoir
Jun 1, 1996·Cancer Metastasis Reviews·R K JainR J Melder
Jul 6, 2000·The American Journal of Pathology·D R Senger, L Van De Water

❮ Previous
Next ❯

Citations

Jun 19, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Roland HaubnerXiaoyuan Chen
Mar 28, 2008·Cancer Chemotherapy and Pharmacology·Matthew E HardeeMark W Dewhirst
Sep 28, 1998·Cancer Chemotherapy and Pharmacology·A L BoralB A Chabner
Nov 30, 2005·Histochemistry and Cell Biology·N Hansen-AlgenstaedtS Ergün
Aug 6, 2009·Molecules and Cells·Chang Hoon Ha, Zheng Gen Jin
Apr 2, 2013·Angiogenesis·E M ProkopiouJ J Walsh
Apr 27, 2007·Cancer Metastasis Reviews·Richard Sullivan, Charles H Graham
Mar 8, 2008·Clinical & Experimental Metastasis·Toshio KuwaiIsaiah J Fidler
Nov 11, 2008·Pharmaceutical Research·C S YoonJ H Park
Sep 3, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Greg M Thurber, Ralph Weissleder
Oct 20, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Keith M StantzKathy D Miller
Jan 19, 2013·Paediatric Drugs·Trent R HummelDavid Franz
Jun 18, 2005·Biochemical and Biophysical Research Communications·Napoleone FerraraWilliam Novotny
Apr 5, 2003·Journal of Molecular and Cellular Cardiology·Vishnu ChintalgattuLaxmansa C Katwa
Oct 8, 1999·Pharmacology & Therapeutics·G M Dubowchik, M A Walker
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·R K Jain
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·R A Brekken, P E Thorpe
Sep 19, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·R K Jain
Mar 22, 2001·Advanced Drug Delivery Reviews·R K Jain
Jul 7, 1997·Advanced Drug Delivery Reviews·R K Jain
Jun 28, 2003·International Journal of Radiation Oncology, Biology, Physics·Alexander F DeVriesWerner Judmaier
Dec 5, 2000·Current Opinion in Biotechnology·N Ferrara
Apr 22, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M TomisawaM Nakamura
Feb 13, 2001·Critical Reviews in Oncology/hematology·G Gasparini
May 23, 2001·Drug Discovery Today·D J. HicklinP Bohlen
Sep 29, 2001·Drug Discovery Today·A Matter
Apr 19, 2002·International Immunopharmacology·Keiko IshiharaMasataka Majima
Oct 14, 2011·Zygote : the Biology of Gametes and Early Embryos·Valdevane Rocha AraújoJosé Ricardo de Figueiredo
Jul 1, 2009·Expert Reviews in Molecular Medicine·Puneet KumarSarah Y Yuan
Oct 23, 2013·Inorganic Chemistry·Christopher M LemonDaniel G Nocera
Mar 5, 1999·Breast Cancer Research and Treatment·N LocopoG Gasparini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.