Time-domain heart rate variability-based computer-aided prognosis of lung cancer

Indian Journal of Cancer
Reema Shyamsunder Shukla, Yogender Aggarwal

Abstract

Incidence of lung cancer (LC) is increasing day by day with exposure to smoke, radiation, and chemicals; LC is one of the leading causes of death. The major difficulty in treatment was delayed diagnosis. This study aims to propose a time-domain heart rate variability (HRV) feature-based automated system in LC prediction and its staging. HRV analysis was done using recorded electrocardiographic signal from 104 LC participants and 30 control volunteers. Artificial neural network (ANN) and support vector machine (SVM) were implemented on HRV time-domain features for early prognosis of the disorder. Statistical significance of HRV parameters was tested, and graphical user interface (GUI) was also implemented. It was revealed that progression of cancer causes low HRV. An accuracy of 89.64% and 100% was obtained with ANN and SVM, respectively, in automated cancer prediction. Statistical analysis suggested the significance of data at P < 0.05 between different performance statuses among patients. The severity of LC alters the sympathovagal balance through autonomic dysfunction. HRV analysis with an expert system was found useful for the early diagnosis of the disease, and thus, a noninvasive technique is of prognostic importance in cl...Continue Reading

References

Jun 1, 1978·Environmental Research·R B Schlesinger, M Lippmann
Sep 27, 2002·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Declan Walsh, Kristine A Nelson
Jan 1, 1962·Radiology·L H GARLANDR L STEIN
Nov 18, 2006·Medical & Biological Engineering & Computing·U Rajendra AcharyaJasjit S Suri
Nov 29, 2007·Journal of Medical Systems·Yogender AggarwalRakesh Kumar Sinha
Aug 3, 2010·Journal of Korean Medical Science·Do Hoon KimYoung Eun Kim
Apr 20, 2013·Oncology Letters·Sha LiDongwei Gao
Sep 24, 2013·Computer Methods and Programs in Biomedicine·Mika P TarvainenPasi A Karjalainen
Jan 27, 2015·Biological Research for Nursing·Elena Caro-MoránLourdes Díaz-Rodríguez
Dec 3, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ying GuoSyed Wamique Yusuf
Sep 15, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Viroj Wiwanitkit

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Citations

Sep 5, 2020·Clinical Physiology and Functional Imaging·Udi Nussinovitch
Dec 1, 2020·Physical and Engineering Sciences in Medicine·Yogender AggarwalRakesh Kumar Sinha

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