Time-elapsed synchrotron-light microstructural imaging of femoral neck fracture

Journal of the Mechanical Behavior of Biomedical Materials
Saulo Martelli, Egon Perilli

Abstract

Time-elapsed micro-computed-tomography (μCT) imaging allows studying bone micromechanics. However, no study has yet performed time-elapsed μCT imaging of human femoral neck fractures. We developed a protocol for time-elapsed synchrotron μCT imaging of the microstructure in the entire proximal femur, while inducing clinically-relevant femoral neck fractures. Three human cadaver femora (females, age: 75-80 years) were used. The specimen-specific force to be applied at each load step was based on the specimens' strength estimated a priori using finite-element analysis of clinical CT images. A radio-transparent compressive stage was designed for loading the specimens while recording the applied load during synchrotron μCT scanning. The total μCT scanning field of view was 146 mm wide and 131 mm high, at 29.81 µm isotropic pixel size. Specimens were first scanned unloaded, then under incremental load steps, each equal to 25% of the estimated specimens' strength, and ultimately after fracture. Fracture occurred after 4-5 time-elapsed load steps, displaying sub-capital fracturing of the femoral neck, in agreement with finite-element predictions. Time-elapsed μCT images, co-registered to those of the intact specimen, displayed the prox...Continue Reading

Citations

Apr 30, 2019·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Christopher Hall, Robert Lewis
Feb 20, 2020·Journal of Microscopy·J DewanckeleA P Merkle
Jul 26, 2019·Annals of Biomedical Engineering·Dale L RobinsonPeter Vee Sin Lee
Apr 27, 2020·Current Osteoporosis Reports·Saulo MartelliMark Taylor
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Sophie Le CannHanna Isaksson
Jan 18, 2021·Acta Biomaterialia·Saulo MartelliEgon Perilli
Nov 14, 2020·Annals of Biomedical Engineering·Marco PalancaSaulo Martelli

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