Time Evolution of DOTATOC Uptake in Neuroendocrine Tumors in View of a Possible Application of Radioguided Surgery with β- Decay

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
F CollamatiR Faccini

Abstract

A novel radioguided surgery (RGS) technique exploiting β- radiation has been proposed. To develop such a technique, a suitable radiotracer able to deliver a β- emitter to the tumor has to be identified. A first candidate is represented by 90Y-labeled DOTATOC, a compound commonly used today for peptide radioreceptor therapy. The application of this β- RGS to neuroendocrine tumors (NET) requires study of the uptake of DOTATOC and its time evolution both in tumors and in healthy organs and evaluation of the corresponding performance of the technique. Uptake by lesions and healthy organs (kidneys, spleen, liver and healthy muscle) was estimated on 177Lu-DOTATOC SPECT/CT scans of 15 patients affected by NET with different localizations, treated at IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy. For each patient, SPECT/CT images, acquired at 0.5, 4, 20, 40, and 70 h after injection, were studied. For each lesion, the tumor-to-nontumor ratio (TNR) with respect to all healthy organs and its time evolution were studied. A subset of patients showing hepatic lesions was selected, and the TNR with respect to the nearby healthy tissue was calculated. By means of a Monte Carlo simulation of the probe for β- RGS, the activity that ...Continue Reading

References

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Mar 22, 2014·Scientific Reports·E Solfaroli CamillocciR Faccini
Dec 17, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Francesco CollamatiRiccardo Faccini

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Citations

Oct 7, 2018·Medical Physics·Marija Z JeremicDragoslav R Nikezic
Nov 6, 2018·Scientific Reports·Francesco CollamatiElena Solfaroli Camillocci
Mar 7, 2020·Scientific Reports·Francesco CollamatiRiccardo Faccini
Feb 20, 2021·Cancer Biotherapy & Radiopharmaceuticals·Emilio BertaniChiara M Grana

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