Abstract
Time in range is a key glycemic metric, and comparisons of management technologies for this outcome are critical to guide device selection. We conducted a systematic review and network meta-analysis to compare and rank technologies for time in glycemic ranges. We searched Evidenced-Based Medicine Reviews, CINAHL, Embase, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, PROSPERO, PsycInfo, PubMed, and Web of Science until 24 April 2019. We included randomized controlled trials ≥2 weeks' duration comparing technologies for management of type 1 diabetes in adults (≥18 years of age), excluding pregnant women. Data were extracted using a predefined template. Outcomes were percent time with sensor glucose levels 3.9-10.0 mmol/L (70-180 mg/dL), >10.0 mmol/L (180 mg/dL), and <3.9 mmol/L (70 mg/dL). We identified 16,772 publications, of which 14 eligible studies compared eight technologies comprising 1,043 participants. Closed-loop systems led to greater percent time in range than any other management strategy, and mean percent time in range was 17.85 (95% predictive interval 7.56-28.14) longer than with usual care of multiple daily injections with capillary glucose testing. Closed-loop systems ranked best for percent time in ...Continue Reading
References
Apr 26, 2008·BMJ : British Medical Journal·Gordon H GuyattUNKNOWN GRADE Working Group
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
Apr 9, 2011·BMC Medical Research Methodology·Jack BowdenSarah Burdett
Jun 15, 2011·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·David C HoaglinAnnabel Barrett
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Sep 22, 2012·The Journal of Clinical Endocrinology and Metabolism·Roy W BeckUNKNOWN T1D Exchange Clinic Network
Oct 8, 2013·PloS One·Anna ChaimaniGeorgia Salanti
Dec 21, 2013·Diabetes Care·David M Nathan, UNKNOWN DCCT/EDIC Research Group
Jul 6, 2014·PloS One·Georgia SalantiJulian P T Higgins
May 23, 2015·Diabetes Care·Kellee M MillerUNKNOWN T1D Exchange Clinic Network
Jun 2, 2015·Annals of Internal Medicine·Brian HuttonDavid Moher
Sep 26, 2015·The Laryngoscope·Yun LiuShuang Zhang
May 29, 2016·Journal of Diabetes Science and Technology·Diana NaranjoKorey K Hood
Jul 21, 2016·European Archives of Psychiatry and Clinical Neuroscience·Stefan LeuchtGeorgia Salanti
Nov 16, 2016·Bulletin of the World Health Organization·Steve KantersNick Bansback
May 24, 2017·The Lancet. Diabetes & Endocrinology·Alanna WeismanBruce A Perkins
Jul 25, 2017·Diabetes Care·Roy W BeckRichard M Bergenstal
Nov 23, 2017·Diabetes Care·Matthew C RiddleWilliam T Cefalu
Nov 23, 2017·Diabetes Care·Thomas DanneMoshe Phillip
Mar 14, 2018·Systematic Reviews·Anthony PeaseSophia Zoungas
Apr 3, 2018·Diabetes Technology & Therapeutics·Arndís F ÓlafsdóttirMarcus Lind
Apr 20, 2018·BMJ : British Medical Journal·Eleni BekiariApostolos Tsapas
May 23, 2018·Diabetes Care·UNKNOWN Beyond A1C Writing Group
Oct 26, 2018·Diabetes Care·Roy W BeckKelly L Close
Dec 24, 2018·Diabetes Technology & Therapeutics·Robert A Vigersky, Chantal McMahon
Jan 15, 2019·Journal of Diabetes Science and Technology·Roy W BeckDavid Rodbard
Jun 10, 2019·Diabetes Care·Tadej BattelinoMoshe Phillip
Sep 25, 2019·Diabetes Care·Rayhan A LalDarrell M Wilson
Citations
Jan 13, 2021·Diabetes Care·Maria J RedondoLinda A DiMeglio
Dec 15, 2020·Diabetes Research and Clinical Practice·Anthony PeaseSophia Zoungas
Oct 16, 2020·Diabetes Care·Sybil A McAuleyUNKNOWN Australian JDRF Closed-Loop Research Group
Apr 12, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Pilar I Beato-VíboraAna Ambrojo-López
Jun 21, 2021·The Medical Journal of Australia·Anthony J PeaseGlynis P Ross
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Alfredo Daniel GuerrónFrancisco J Pasquel
Sep 1, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·José Ribeiro
Sep 22, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Hood ThabitLalantha Leelarathna
Aug 8, 2021·Diabetes Care·Melissa H LeeDavid N O'Neal