Time in Range for Multiple Technologies in Type 1 Diabetes: A Systematic Review and Network Meta-analysis.

Diabetes Care
Anthony PeaseSophia Zoungas

Abstract

Time in range is a key glycemic metric, and comparisons of management technologies for this outcome are critical to guide device selection. We conducted a systematic review and network meta-analysis to compare and rank technologies for time in glycemic ranges. We searched Evidenced-Based Medicine Reviews, CINAHL, Embase, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, PROSPERO, PsycInfo, PubMed, and Web of Science until 24 April 2019. We included randomized controlled trials ≥2 weeks' duration comparing technologies for management of type 1 diabetes in adults (≥18 years of age), excluding pregnant women. Data were extracted using a predefined template. Outcomes were percent time with sensor glucose levels 3.9-10.0 mmol/L (70-180 mg/dL), >10.0 mmol/L (180 mg/dL), and <3.9 mmol/L (70 mg/dL). We identified 16,772 publications, of which 14 eligible studies compared eight technologies comprising 1,043 participants. Closed-loop systems led to greater percent time in range than any other management strategy, and mean percent time in range was 17.85 (95% predictive interval 7.56-28.14) longer than with usual care of multiple daily injections with capillary glucose testing. Closed-loop systems ranked best for percent time in ...Continue Reading

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Citations

Apr 12, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Pilar I Beato-VíboraAna Ambrojo-López
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Alfredo Daniel GuerrónFrancisco J Pasquel
Sep 1, 2021·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·José Ribeiro
Sep 22, 2021·Diabetic Medicine : a Journal of the British Diabetic Association·Hood ThabitLalantha Leelarathna

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