Time in Specific Glucose Ranges, Glucose Management Indicator, and Glycemic Variability: Impact of Continuous Glucose Monitoring (CGM) System Model and Sensor on CGM Metrics.

Journal of Diabetes Science and Technology
Stefan PleusGuido Freckmann

Abstract

International consensus recommends a set of continuous glucose monitoring (CGM) metrics to assess quality of diabetes therapy. The impact of individual CGM sensors on these metrics has not been thoroughly studied yet. This post hoc analysis aimed at comparing time in specific glucose ranges, coefficient of variation (CV) of glucose concentrations, and glucose management indicator (GMI) between different CGM systems and different sensors of the same system. A total of 20 subjects each wore two Dexcom G5 (G5) sensors and two FreeStyle Libre (FL) sensors for 14 days in parallel. Times in ranges, GMI, and CV were calculated for each 14-day sensor experiment, with up to four sensor experiments per subject. Pairwise differences between different sensors of the same CGM system as well as between sensors of different CGM system were calculated for these metrics. Pairwise differences between sensors of the same model showed larger differences and larger variability for FL than for G5, with some subjects showing considerable differences between the two sensors. When pairwise differences between sensors of different CGM models were calculated, substantial differences were found in some subjects (75th percentiles of differences of time spe...Continue Reading

References

Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jun 10, 1993·The New England Journal of Medicine·D M Nathan
Jan 16, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Randie R Little, Curt L Rohlfing
Feb 19, 2015·Journal of Diabetes Science and Technology·Lutz Heinemann, Guido Freckmann
Nov 23, 2017·Diabetes Care·Thomas DanneMoshe Phillip
Aug 2, 2018·Diabetes Technology & Therapeutics·Guido FreckmannCornelia Haug
Feb 8, 2019·Journal of Diabetes Science and Technology·Guido FreckmannRaimund Weitgasser
Jul 4, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·I B HirschD A Price

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Citations

Jan 30, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Guido FreckmannAndreas Stuhr
Feb 23, 2021·Journal of Diabetes Science and Technology·Stefan PleusGuido Freckmann

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