Time in Therapeutic Range and Disease Outcomes in Elderly Japanese Patients With Nonvalvular Atrial Fibrillation

Circulation Journal : Official Journal of the Japanese Circulation Society
Hiroshi InoueJ-RHYTHM Registry Investigators

Abstract

The relationship between warfarin treatment quality and prognosis for Japanese patients with nonvalvular atrial fibrillation (NVAF) has not been studied thoroughly. Methods and Results: Data from the J-RHYTHM Registry were used to determine the time in therapeutic range (TTR) of the international normalized ratio (INR) of prothrombin time in elderly patients (≥70 years). Target INR was 1.6-2.6. Of 7,406 patients with NVAF in the database, 3,832 elderly patients (mean [±SD] age 77.0±5.0 years) constituted the study group. Of these patients, 459 did not receive warfarin and 3,373 received warfarin. Patients on warfarin were subdivided into 4 TTR groups: <40%, 40-59.9%, 60-79.9%, and ≥80%. During the 2-year follow-up, the incidence of thromboembolism and all-cause death was lower in patients with higher TTR (Ptrend<0.001); however, the incidence of major hemorrhage was higher in patients with TTR <40%. In multivariate analysis, compared with the no-warfarin group, TTR 60-79.9% and ≥80% were associated with lower thromboembolic risk, with hazard ratios (HR) of 0.34 (95% confidence interval [CI] 0.17-0.67; P=0.002) and 0.35 (95% CI 0.18-0.68; P=0.002), respectively, and lower all-cause death (HR 0.37 [95% CI 0.22-0.65; P<0.001] and ...Continue Reading

References

Jun 13, 2001·JAMA : the Journal of the American Medical Association·B F GageM J Radford
Dec 25, 2009·Circulation. Cardiovascular Quality and Outcomes·Yi WanYongyong Xu
Apr 7, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Hirotsugu AtarashiUNKNOWN J-RHYTHM Registry Investigators
May 28, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi InoueUNKNOWN J-RHYTHM Registry Investigators
Jan 28, 2014·The American Journal of Cardiology·Hiroshi InoueUNKNOWN J-RHYTHM Registry Investigators
Jun 27, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Aug 8, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroshi InoueHideki Origasa
Oct 31, 2015·Stroke; a Journal of Cerebral Circulation·Kensuke TakabayashiMasaharu Akao
Mar 24, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Eitaro KodaniUNKNOWN J-RHYTHM Registry Investigators
Jul 22, 2016·JAMA Cardiology·Fredrik BjörckAnders Själander
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Sep 21, 2016·Heart·A John CammUNKNOWN GARFIELD-AF Investigators
Apr 22, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Yugo YamashitaMasaharu Akao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

Circulation Journal : Official Journal of the Japanese Circulation Society
Hiroshi InoueJ-RHYTHM Registry Investigators
Circulation Journal : Official Journal of the Japanese Circulation Society
Eitaro KodaniJ-RHYTHM Registry Investigators
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Eitaro KodaniJ-RHYTHM Registry Investigators
© 2022 Meta ULC. All rights reserved