Time-integrated blood lead concentration is a valid surrogate for estimating the cumulative lead dose assessed by tibial lead measurement

Environmental Research
H A RoelsR Lauwerys

Abstract

The concentration of lead in tibia (Pb-T) was measured in vivo by a 109Cd K-shell X-ray fluorescence technique in 123 workers from a primary lead smelter (age: mean, 45 years; range, 30-61; duration of employment: mean, 20 years; range, 7-45). Their cumulative blood lead index (CBLI) was also calculated on the basis of the blood lead (Pb-B) records available from the company's medical files. Geometric mean for Pb-T was 49 micrograms Pb/g bone mineral (range, 15-167). The company's health surveillance programs, implemented since 1945, resulted in Pb-B values which rarely exceeded 70 micrograms Pb/dl whole blood. Pb-B at the time of Pb-T measurement averaged 31 micrograms Pb/dl (range, 6-62) and the geometric mean for CBLI amounted to 803 micrograms Pb/dl x year (range, 220-2130). Despite various assumptions and uncertainties inherent in the assessment of the cumulative lead dose through Pb-T measurement or CBLI calculation, the relation between both variables in the present lead smelter populations is very strong (rpearson = 0.80, P < 0.0001; age explained at the most 9.5% of the variance). The slope of the regression equation of log Pb-T vs log CBLI showed that a doubling of CBLI also corresponds to doubling of Pb-T. It may be ...Continue Reading

Citations

Aug 10, 2000·Occupational and Environmental Medicine·H Y ChuangH Hu
Feb 13, 2001·Occupational and Environmental Medicine·A C ToddB S Schwartz
Apr 7, 2005·Environmental Health Perspectives·Marija PopovicWendy E Kaye
Feb 1, 1997·Environmental Health Perspectives·D E FlemingD R Chettle
Apr 14, 2007·Environmental Health Perspectives·Howard HuBrian S Schwartz
Dec 23, 1998·Environmental Health Perspectives·P Mushak
May 19, 2006·International Journal of Environmental Research and Public Health·Vladislav KondrashovStephen J Rothenberg
Feb 6, 2009·The Science of the Total Environment·Shu-Jung HsiehHung-Yi Chuang
Feb 23, 2012·Occupational Medicine·Ali Hashtroudi
Sep 1, 2007·Physics in Medicine and Biology·M PopovicF E McNeill
Apr 6, 2006·American Journal of Industrial Medicine·Pau-Chung ChenJung-Der Wang
Feb 22, 2007·American Journal of Industrial Medicine·Walter F Stewart, Brian S Schwartz
Nov 16, 2012·Journal of Environmental Monitoring : JEM·Sepideh BehinaeinSusan Stever
Apr 29, 2020·International Journal of Environmental Research and Public Health·Hsin-Liang LiuKuan-Ting Liu
Aug 9, 2001·American Journal of Industrial Medicine·A C ToddS H Liou
Aug 17, 2004·Journal of Occupational Health·Hung-Yi ChuangTrong-Neng Wu
Jan 22, 2005·American Journal of Industrial Medicine·Patricia CoyleKaren Hipkins

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