Jun 28, 2013

Time is of the essence for ParaHox homeobox gene clustering

BMC Biology
Myles Garstang, David E K Ferrier

Abstract

ParaHox genes, and their evolutionary sisters the Hox genes, are integral to patterning the anterior-posterior axis of most animals. Like the Hox genes, ParaHox genes can be clustered and exhibit the phenomenon of colinearity - gene order within the cluster matching gene activation. Two new instances of ParaHox clustering provide the first examples of intact clusters outside chordates, with gene expression lending weight to the argument that temporal colinearity is the key to understanding clustering.

  • References11
  • Citations8

Citations

Mentioned in this Paper

Genes, Reiterated
Gene Expression
Phylogeny
Homeodomain Proteins
Chordata
Genes, Homeobox
Homeo Box Sequence
Posterior Pituitary Disease
Evolution, Molecular
Gene Order

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