Time modulated prefrontal and parietal activity during the maintenance of integrated information as revealed by magnetoencephalography

Cerebral Cortex
Pablo CampoCarlos Amo

Abstract

Using magnetoencephalography, we investigated the spatiotemporal patterns of brain magnetic activity responsible for maintaining verbal and spatial information in either an integrated or an unintegrated fashion. Considering time dimension, we noted a greater activation of a fronto-parietal network in early latencies during the maintenance of integrated information, and a different pattern during the maintenance of unintegrated material, showing a greater activation in a fronto-posterior network in late latencies. The greater activation found in certain areas which are traditionally reported as being engaged in spatial working memory (i.e. superior frontal gyri, dorsolateral prefrontal cortex, superior and inferior parietal lobes) when subjects maintained integrated information could be explained by a greater weight of the spatial dimension. It is as if words somehow acquired a spatial attribute, thus exerting a greater load in a neural network specialized in spatial working memory. Alternatively, and not mutually exclusive, we also propose that during the maintenance of integrated information the allocation of cognitive resources is less interfering than during the maintenance of unintegrated information, making it easier.

Citations

Jun 10, 2010·Cerebral Cortex·Simone RossiStefano F Cappa
Nov 19, 2015·Psychopharmacology·Brian Stollery, Leonie Christian
Mar 1, 2005·NeuroImage·Pablo CampoAlberto Fernández
May 3, 2014·Neuropsychologia·Richard J AllenAlan D Baddeley
Mar 9, 2006·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Paul M WalshLiam Murray
Apr 17, 2009·The Quarterly Journal of Experimental Psychology : QJEP·Candice C Morey
Sep 13, 2005·Biological Psychiatry·Fernando MulasTomás Ortiz

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