Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock.

The Journal of Physiology
Denise KemlerKaryn A Esser

Abstract

Disruptions in circadian rhythms across an organism are associated with negative health outcomes, such as cardiometabolic and neurodegenerative diseases. Exercise has been proposed as a time cue for the circadian clock in rodents and humans. In this study, we assessed the effect of a single bout of endurance exercise on the skeletal muscle clock in vivo and a bout of muscle contractions in vitro. Timing of exercise or contractions influences the directional response of the muscle clock phase in vivo and in vitro. Our findings demonstrate that muscle contractions, as a component of exercise, can directly modulate the expression of muscle clock components in a time-of-day dependent manner. Exercise has been proposed to be a zeitgeber for the muscle circadian clock mechanism. However, this is not well defined and it is unknown if exercise timing induces directional shifts of the muscle clock. Our purpose herein was to assess the effect of one bout of treadmill exercise on skeletal muscle clock phase changes. We subjected PERIOD2::LUCIFERASE mice (n = 30F) to one 60 min treadmill exercise bout at three times of day. Exercise at ZT5, 5 h after lights on, induced a phase advance (100.2 ± 25.8 min; P = 0.0002), whereas exercise at ZT1...Continue Reading

References

Aug 19, 1977·Science·A T Winfree
Jun 1, 1991·Journal of Applied Physiology·R R RoyV R Edgerton
Oct 1, 1991·The American Journal of Physiology·D M Edgar, W C Dement
Feb 1, 1984·The American Journal of Physiology·L Glass, A T Winfree
Aug 1, 1981·Photochemistry and Photobiology·B Rusak, Z Boulos
Dec 1, 1995·Physiology & Behavior·C I EastmanL Liu
Aug 1, 1996·Biological Reviews of the Cambridge Philosophical Society·N Mrosovsky
Aug 1, 1996·Physiology & Behavior·E G Marchant, R E Mistlberger
Dec 10, 1999·Chronobiology International·C H Johnson
Apr 12, 2001·Journal of Applied Physiology·G A Nader, K A Esser
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T MiyazakiK I Honma
Oct 2, 2003·Genome Biology·Alexander C ZambonBruce R Conklin
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Mar 12, 2004·Neurobiology of Aging·Daniel E KolkerFred W Turek
Mar 17, 2004·Brain Research. Gene Expression Patterns·E S Maywood, N Mrosovsky
Aug 4, 2005·Journal of Biological Rhythms·Ralph E Mistlberger, Debra J Skene
Oct 14, 2005·EMBO Reports·Martha MerrowTill Roenneberg
Sep 22, 2006·Human Molecular Genetics·Caroline H Ko, Joseph S Takahashi
Nov 14, 2006·PLoS Genetics·Darius BalciunasStephen C Ekker
Jun 7, 2007·Physiological Genomics·John J McCarthyKaryn A Esser
Apr 24, 2008·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yujiro YamanakaKen-ichi Honma
May 24, 2008·Science·Patrick M FullerClifford B Saper
Jul 3, 2008·Genes & Development·Justin Blau
Apr 4, 2009·PLoS Genetics·Michael E HughesJohn B Hogenesch
Jul 29, 2010·Physiological Reviews·Diego A Golombek, Ruth E Rosenstein
Aug 9, 2011·Essays in Biochemistry·Ralph E Mistlberger, Michael C Antle
Mar 22, 2012·Endocrinology·Mitsugu SujinoYasufumi Shigeyoshi
Mar 31, 2012·Medicine and Science in Sports and Exercise·Gretchen Wolff, Karyn A Esser
Apr 10, 2012·Annual Review of Neuroscience·Jennifer A MohawkJoseph S Takahashi
Nov 28, 2012·Nucleic Acids Research·Angel PizarroJohn B Hogenesch
Jan 1, 2007·Biological Rhythm Research·Roberto RefinettiFranz Halberg
Aug 6, 2013·Current Biology : CB·Kenneth P WrightEvan D Chinoy
Aug 7, 2013·Trends in Cell Biology·Carrie L PartchJoseph S Takahashi
Oct 5, 2013·Disease Models & Mechanisms·Fabio DemontisNorbert Perrimon
Jun 16, 2015·Scientific Reports·Yu TaharaShigenobu Shibata
Oct 22, 2015·The Journal of Physiology·Elizabeth A SchroderKaryn A Esser
Dec 20, 2015·Cold Spring Harbor Symposia on Quantitative Biology·Ueli SchiblerPaul Franken

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Citations

Jul 25, 2020·The Journal of Physiology·Nicholas J Saner, Matthew J-C Lee
Sep 20, 2020·The Journal of Physiology·Christopher A Wolff, Karyn A Esser
Sep 18, 2020·The Journal of Physiology·Lewin SmallRomain Barrès
Jan 12, 2021·Médecine sciences : M/S·Alicia Mayeuf-Louchart
Jan 20, 2021·Cellular and Molecular Life Sciences : CMLS·Susanne KlausMario Ost
Mar 12, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ziad S MahmassaniMicah J Drummond
May 9, 2021·The Journal of Physiology·Brendan M Gabriel, Juleen R Zierath
Aug 3, 2021·The Journal of Physiology·Tomer Jordi ChafferJean-Philippe Leduc-Gaudet
Sep 21, 2021·American Journal of Physiology. Endocrinology and Metabolism·Abigail L TiceJennifer L Steiner
Jan 15, 2022·Cell Metabolism·Shogo SatoPaolo Sassone-Corsi

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Methods Mentioned

BETA
PCR

Key Resources (RRID) Mentioned

CVCL_UR38
Addgene_31829
Addgene_31823
SCR_017962
SCR_002798

Software Mentioned

CircaDB
JTK
GraphPad Prism

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