Time-of-day dependent pharmacodynamic and pharmacokinetic profiles of caffeine in rats

Naunyn-Schmiedeberg's Archives of Pharmacology
Anne-Laure Pelissier-AlicotB Bruguerolle

Abstract

This study aims to investigate the effects of caffeine on the daily rhythms of heart rate (HR), body temperature (BT) and locomotor activity (LA) in rats in relation to time-of-day of administration, as well as their possible mechanisms, particularly related to caffeine pharmacokinetics. During the pharmacodynamic study, HR, BT and LA were measured every 10 min by radiotelemetry and analysed by Cosinor. This study was divided into three periods: a control period P1, a treatment period P2 and a recovery period P3. During P2, rats of the morning group ( M(tel)) received a 25 mg/kg s.c. dose of caffeine at 08.00 while rats of the evening group ( E(tel)) received the same dose of caffeine at 20.00. The pharmacokinetic study was conducted in parallel with the telemetric study and was divided into two periods: a control period P1, and a treatment period P2. During P2, animals of the morning ( M(pk)) and the evening ( E(pk)) groups received the same treatment as the animals of the telemetric study. At the last day of P2, blood samples were drawn 0.25, 0.5, 1, 2, 4, 8, 12 and 24 h after the last morning and the last evening administration in order to determine the pharmacokinetics of M(pk) and E(pk). Our results showed that morning adm...Continue Reading

Citations

Mar 4, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert L BrentRobert M Diener
Feb 15, 2020·British Journal of Pharmacology·Joana BickerAna Fortuna

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