Time-of-Day Effects on Metabolic and Clock-Related Adjustments to Cold

Frontiers in Endocrinology
Frederico Sander Mansur MachadoAndries Kalsbeek

Abstract

Daily cyclic changes in environmental conditions are key signals for anticipatory and adaptive adjustments of most living species, including mammals. Lower ambient temperature stimulates the thermogenic activity of brown adipose tissue (BAT) and skeletal muscle. Given that the molecular components of the endogenous biological clock interact with thermal and metabolic mechanisms directly involved in the defense of body temperature, the present study evaluated the differential homeostatic responses to a cold stimulus at distinct time-windows of the light/dark-cycle. Male Wistar rats were subjected to a single episode of 3 h cold ambient temperature (4°C) at one of 6 time-points starting at Zeitgeber Times 3, 7, 11, 15, 19, and 23. Metabolic rate, core body temperature, locomotor activity (LA), feeding, and drinking behaviors were recorded during control and cold conditions at each time-point. Immediately after the stimulus, rats were euthanized and both the soleus and BAT were collected for real-time PCR. During the light phase (i.e., inactive phase), cold exposure resulted in a slight hyperthermia (p < 0.001). Light phase cold exposure also increased metabolic rate and LA (p < 0.001). In addition, the prevalence of fat oxidative...Continue Reading

References

Oct 1, 1978·The Journal of Physiology·M BanetH Liebermann
Dec 1, 1976·Perceptual and Motor Skills·F W Finger
May 1, 1990·Physiology & Behavior·C J Gordon
Jun 1, 1967·Metabolism: Clinical and Experimental·J A LennonE S Gordon
Jun 1, 1997·Journal of Biological Rhythms·M WachulecE Satinoff
Apr 4, 2000·Journal of Thermal Biology·H Gautier
Apr 15, 2000·Nature·B B Lowell, B M Spiegelman
Aug 14, 2001·American Journal of Physiology. Endocrinology and Metabolism·L C Navegantes Kettelhut IC
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Oct 10, 2002·Current Biology : CB·Steven A BrownUeli Schibler
Mar 1, 1960·The American Journal of Physiology·T R DAVISB J CREMER
Sep 23, 2003·Brain Research·Samuel Deurveilher, Kazue Semba
Nov 26, 2003·Journal of Neuroendocrinology·A KalsbeekR M Buijs
Dec 25, 2003·The Proceedings of the Nutrition Society·Patrick Schrauwen, Matthijs Hesselink
May 14, 2004·American Journal of Physiology. Endocrinology and Metabolism·Debby P Y KoonenArend Bonen
May 29, 2004·American Journal of Physiology. Endocrinology and Metabolism·Rachel L G S OliveiraLício A Velloso
Jul 20, 2005·Acta Physiologica Scandinavica·J-M Weber, F Haman
Apr 15, 2006·Journal of Applied Physiology·François Haman
Nov 4, 2006·Journal of Applied Physiology·Damien Freyssenet
Jan 5, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Véronic BézaireMary-Ellen Harper
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lindsay M RohasBruce M Spiegelman
Aug 19, 2007·Physiology·Stefano SchiaffinoMarta Murgia
Dec 7, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·James G NickersonArend Bonen
Mar 13, 2008·PloS One·Sander L J WijersWouter D van Marken Lichtenbelt
Dec 29, 2009·Frontiers in Bioscience (Landmark Edition)·Roberto Refinetti
Mar 10, 2010·Biochimica Et Biophysica Acta·Vian AzzuMartin D Brand
Oct 16, 2010·Science·Ethan D BuhrJoseph S Takahashi
Apr 20, 2011·Current Opinion in Clinical Nutrition and Metabolic Care·Theodore P Braun, Daniel L Marks
May 26, 2011·The Journal of Physiology·Kazuhiro Nakamura, Shaun F Morrison
Mar 31, 2012·Medicine and Science in Sports and Exercise·Gretchen Wolff, Karyn A Esser
May 9, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Julien DelezieEtienne Challet

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Citations

Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Marine AdlanmeriniMitchell A Lazar
Jan 1, 2019·Journal of Pineal Research·Caroline A P de SouzaFernanda G do Amaral
Dec 1, 2020·Temperature : Multidisciplinary Biomedical Journal·Roberto Refinetti

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Methods Mentioned

BETA
chips
PCR

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