Time of initiation of clomiphene citrate and pregnancy rate in polycystic ovarian syndrome

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
S DehbashiS Alborzi

Abstract

To investigate whether the timing of clomiphene citrate (CC) administration affects hormonal levels, follicular growth, endometrial thickness, and ovulation and pregnancy rates in women with polycystic ovarian syndrome (PCOS). Of the 78 infertile women with PCOS who participated in this prospective, double-blind, randomized clinical trial, 37 collectively underwent 71 cycles of CC (100 mg/day) on days 1 through 5 of the menstrual cycle (group 1) and 41 collectively underwent 73 cycles of CC at the same concentration on days 5 through 9 (group 2). Hormonal levels, follicular growth, endometrial thickness, and ovulation and pregnancy rates were compared. The mean number of follicles and the maximum follicular size were greater in group 2. However, ovulation rates were 72.8% in group 1 and 70.8% in group 2 (P=.78), and pregnancy rates were 40.5% in group 1 and 19.5% in group 2 (P=.04). Treatment with CC is associated with higher rates of pregnancy if started early (days 1-5) in the menstrual cycle.

References

Oct 1, 1989·Fertility and Sterility·C H Wu, C A Winkel
Jan 1, 1981·Pharmacology & Therapeutics·J H Clark, B M Markaverich
Jan 16, 2003·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S DehbashiA Zarei

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Citations

May 21, 2014·Archives of Gynecology and Obstetrics·Ozlem KosarMine Islimye Taskin
Mar 19, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Carlos Portocarrero-SanchezMaria Teresinha de Oliveira Cardoso
Dec 29, 2013·Journal of Ovarian Research·Akihisa TakasakiNorihiro Sugino
Apr 30, 2016·The Journal of Obstetrics and Gynaecology Research·Ahmed E H ElbohotyMohamed Abdelmoaz
Jul 19, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nan DingFang Wang
Dec 16, 2016·The Cochrane Database of Systematic Reviews·Julie Brown, Cindy Farquhar
Mar 9, 2019·Archives of Gynecology and Obstetrics·Sajadeh PourghasemMaryam Azizi Kutenaee
May 15, 2007·Current Opinion in Obstetrics & Gynecology

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