Time of Lactation and Maternal Fucosyltransferase Genetic Polymorphisms Determine the Variability in Human Milk Oligosaccharides

Frontiers in Nutrition
Gregory LefebvreAristea Binia

Abstract

Rationale: Human milk oligosaccharides (HMOs) vary among mothers and genetic factors contribute to this variability. We assessed changes in HMO concentrations during the first year of lactation and the relationship with FUT2 Secretor group and FUT3 Lewis group defining genetic polymorphisms. Methods: Milk samples were collected from lactating mothers participating in the LIFE Child cohort in Leipzig, Germany. The concentrations of 24 HMOs in milk samples collected at 3 months (N = 156), 6 months (N = 122), and 12 months (N = 28) were measured using liquid chromatography. Concentrations of HMOs were compared at all time-points and were tested for their associations with FUT2 and FUT3 genetic variations by sPLS regression. Results:FUT2 SNP rs601338 was found to predominantly define the Secretor status Se-: 11.8% and it was highly correlated with 2'-fucosyllactose (2'FL, p < 0.001) and lacto-N-fucosylpentaose-I (LNFP-I, p < 0.001). FUT3 SNPs rs28362459 and rs812936 were found to define Lewis status (Le-: 5.9%) and correlated with lacto-N-fucosylpentaose-II (LNFP-II, p < 0.001). A polygenic score predicted the abundance of 2'FL levels within Secretors' milk (adj. R2 = 0.58, p < 0.001). Mean concentrations of most of the individual ...Continue Reading

References

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Citations

Aug 12, 2021·Immunity·Johanne E Spreckels, Alexandra Zhernakova
Aug 28, 2021·Nutrients·Buket SoyyılmazLouise Kristine Vigsnæs
Oct 15, 2021·PloS One·Humaira ZafarM Iqbal Choudhary

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Datasets Mentioned

BETA
PRJNA643141

Methods Mentioned

BETA
PCR
electrophoresis
exome sequencing

Software Mentioned

FreeBayes
Fragment Analyzer ( AATI
plink

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