Time of transforming growth factor beta 1 inoculation alters the incubation of BSE in mice

Neuroreport
S KempsterN Edington

Abstract

Groups of 20 C57BL/6J mice (10 males and 10 females) were given BSE strain 301C i.p. and subsequently given 2 microg recombinant human TGFbeta1 s.c. at single or multiple times. There was a significant positive correlation between the day of TGFbeta1 administration and incubation time; the later TGFbeta1 was administered after BSE inoculation the longer the incubation time became. The administration of TGFbeta1 at any time point did not significantly alter the distribution or severity of pathology. The effects of TGFbeta1 on BSE pathogenesis appears to be dependent upon its time of administration; early administration shortens the incubation time and late administration lengthens the incubation time.

References

Mar 1, 1992·The Journal of General Virology·A LadoganaM Pocchiari
Jul 1, 1968·Journal of Comparative Pathology·A G DickinsonH Fraser
Jul 1, 1968·Journal of Comparative Pathology·H Fraser, A G Dickinson
Jun 1, 1995·Neurodegeneration : a Journal for Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration·Y L ChungJ Hope
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R McLean, C J Bostock
Feb 14, 2002·The Journal of General Virology·Moira E BruceHugh Fraser
Mar 11, 2003·The Journal of Biological Chemistry·Sylvain LesnéDenis Vivien
Oct 2, 2003·The Journal of Biological Chemistry·Einar M SigurdssonThomas Wisniewski
Aug 11, 2004·Behavioural Brain Research·S KempsterN Edington

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