Time-place learning and memory persist in mice lacking functional Per1 and Per2 clock genes

Journal of Biological Rhythms
C MulderM P Gerkema

Abstract

With time-place learning, animals link a stimulus with the location and the time of day. This ability may optimize resource localization and predator avoidance in daily changing environments. Time-place learning is a suitable task to study the interaction of the circadian system and memory. Previously, we showed that time-place learning in mice depends on the circadian system and Cry1 and/or Cry2 clock genes. We questioned whether time-place learning is Cry specific or also depends on other core molecular clock genes. Here, we show that Per1/Per2 double mutant mice, despite their arrhythmic phenotype, acquire time-place learning similar to wild-type mice. As well as an established role in circadian rhythms, Per genes have also been implicated in the formation and storage of memory. We found no deficiencies in short-term spatial working memory in Per mutant mice compared to wild-type mice. Moreover, both Per mutant and wild-type mice showed similar long-term memory for contextual features of a paradigm (a mild foot shock), measured in trained mice after a 2-month nontesting interval. In contrast, time-place associations were lost in both wild-type and mutant mice after these 2 months, suggesting a lack of maintained long-term me...Continue Reading

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Citations

Jun 17, 2014·General and Comparative Endocrinology·Ana B TinocoEsther Isorna
Aug 2, 2014·Chronobiology International·Cornelis Kees MulderEddy A Van Der Zee
Feb 3, 2016·Frontiers in Behavioral Neuroscience·C K MulderE A Van der Zee
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Dec 31, 2015·Journal of Biological Rhythms·Alexander J Lubinski, Terry L Page
Jan 10, 2017·Frontiers in Behavioral Neuroscience·Vibeke M BruinenbergEddy A van der Zee
May 12, 2017·Frontiers in Neurology·Vibeke M BruinenbergEddy A Van der Zee
Mar 2, 2021·Biochemical Pharmacology·Youri G BolsiusRobbert Havekes
Jun 27, 2018·Physiology & Behavior·Kaitlin H Snider, Karl Obrietan
Apr 24, 2015·Learning & Memory·Cornelis K MulderEddy A Van der Zee
Aug 20, 2015·Learning & Memory·Harini C Krishnan, Lisa C Lyons

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Methods Mentioned

BETA
PCR
PCRs
Genotyping

Software Mentioned

MASCO
Statistix
GraphPad Prism
ACTOVIEW

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