Time profiles and toxicokinetic parameters of key biomarkers of exposure to cypermethrin in orally exposed volunteers compared with previously available kinetic data following permethrin exposure

Journal of Applied Toxicology : JAT
Mylène RatelleMichèle Bouchard

Abstract

Biomonitoring of pyrethroid exposure is largely conducted but human toxicokinetics has not been fully documented. This is essential for a proper interpretation of biomonitoring data. Time profiles and toxicokinetic parameters of key biomarkers of exposure to cypermethrin in orally exposed volunteers have been documented and compared with previously available kinetic data following permethrin dosing. Six volunteers ingested 0.1 mg kg(-1) bodyweight of cypermethrin acutely. The same volunteers were exposed to permethrin earlier. Blood samples were taken over 72 h after treatment and complete timed urine voids were collected over 84 h postdosing. Cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (trans- and cis-DCCA) and 3-phenoxybenzoic acid (3-PBA) metabolites, common to both cypermethrin and permethrin, were quantified. Blood and urinary time courses of all three metabolites were similar following cypermethrin and permethrin exposure. Plasma levels of metabolites reached peak values on average ≈ 5-7 h post-dosing; the elimination phase showed mean apparent half-lives (t½ ) for trans-DCCA, cis-DCCA and 3-PBA of 5.1, 6.9 and 9.2 h, respectively, following cypermethrin treatment as compared to 7.1, 6...Continue Reading

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Citations

Feb 3, 2016·International Archives of Occupational and Environmental Health·Mylène RatelleMichèle Bouchard
Mar 13, 2016·Analytical and Bioanalytical Chemistry·Caroline ChataBrice M R Appenzeller
Dec 30, 2017·Journal of Exposure Science & Environmental Epidemiology·Jonathan Côté, Michèle Bouchard
Oct 9, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Pankajini MallickMiyoung Yoon

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