Time-related aspects of the healthy worker survivor effect

Annals of Epidemiology
David B RichardsonWendy McKelvey

Abstract

Health is important for continued employment and therefore continued accrual of occupational exposure; furthermore, steady employment can benefit health. Consequently, bias can occur in estimates of cumulative exposure-mortality associations. This has been called the healthy worker survivor effect (HWSE). The processes associated with the HWSE tend to lead to variation in mortality rates with time-since-termination of employment, most notably a peak in mortality shortly after termination of employment. We use simulations and an empirical example to demonstrate that time-since-termination can be a confounding factor in analyses of occupational-exposure-mortality associations. Simulation data were generated for 20,000 workers followed for 40 years under a model of no effect of employment duration (a proxy for cumulative exposure) on mortality. Proportional hazards regression methods were used to quantify exposure-mortality associations and evaluate methods to control for the HWSE. Results were derived after 100 iterations of the simulation. Relationships between employment duration and mortality were also investigated in a cohort of 122,247 male utility workers with adjustments for time since termination. Simulation data show a p...Continue Reading

References

Jul 1, 1979·Radiation Research·E S Gilbert, S Marks
Jul 1, 1992·Epidemiology·N Pearce
Mar 20, 1991·JAMA : the Journal of the American Medical Association·S WingE L Frome
Oct 1, 1981·Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association·E Delzell, R R Monson
May 1, 1980·British Journal of Industrial Medicine·K Vinni, M Hakama
Mar 1, 1994·Epidemiology·H M Arrighi, I Hertz-Picciotto

❮ Previous
Next ❯

Citations

Jun 7, 2006·Scandinavian Journal of Public Health·Ulrica von ThieleUlf Lundberg
Jun 18, 2005·Occupational and Environmental Medicine·S Wing, D B Richardson
Apr 24, 2007·Occupational and Environmental Medicine·Misty J HeinJohn M Dement
Apr 24, 2007·Occupational and Environmental Medicine·Katie M ApplebaumEllen A Eisen
Jul 20, 2011·BMC Public Health·Lau C ThygesenHenrik Brønnum-Hansen
Jul 17, 2015·Occupational and Environmental Medicine·Jill F LebovDale P Sandler
May 23, 2015·Occupational and Environmental Medicine·Aimee J PalumboRobert Wallace
Jan 30, 2004·American Journal of Industrial Medicine·Steve WingGary Mihlan
Jun 2, 2011·American Journal of Industrial Medicine·Steven J LippmannJiu-Chiuan Chen
Jan 1, 2014·American Journal of Industrial Medicine·Sharon R SilverStephen J Bertke
Nov 5, 2013·Occupational and Environmental Medicine·Judith M GraberMichael D Attfield
Feb 14, 2007·European Journal of Epidemiology·C LocquetG Vidal-Trecan
Dec 24, 2014·Epidemiology·Jessie P BuckleyJessie K Edwards
Aug 31, 2013·Stroke; a Journal of Cerebral Circulation·Zara A StokholmHenrik A Kolstad
May 6, 2011·Epidemiology·Katie M ApplebaumEllen A Eisen
May 1, 2010·Journal of Occupational and Environmental Medicine·Evelyn P DavilaLora E Fleming
Dec 24, 2005·American Journal of Industrial Medicine·David B Richardson, Steve Wing
Nov 30, 2012·Epidemiology·Zara A StokholmHenrik A Kolstad
Aug 20, 2019·Journal of Exposure Science & Environmental Epidemiology·Irina Guseva CanuSandrine Charles
Mar 23, 2017·Critical Reviews in Toxicology·Matthias Möhner, Andrea Wendt
Jan 7, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Andrew RundlePaolo Vineis
Jul 18, 2017·Current Environmental Health Reports·Daniel M BrownEllen A Eisen
Jan 12, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Tomoyuki KawadaYing-Ji Li
Feb 10, 2019·International Archives of Occupational and Environmental Health·Rachel S D LaneJulian Little

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Incidence & Mortality

Cancer has emerged as a global concern due to its increase in incidence and mortality. Efforts are underway to evaluate and develop action plans to reduce the global burden of cancer. Currently, lung cancer, breast cancer and prostate cancer are the leading causes of cancer mortality. Here is the latest research on cancer incidence and mortality.