Time-related changes in neointimal tissue coverage of a novel Sirolimus eluting stent: Serial observations with optical coherence tomography

Cardiovascular Revascularization Medicine : Including Molecular Interventions
Gioel Gabrio SeccoCarlo Di Mario

Abstract

DES has reduced rates of restenosis compared with BMS but it has been associated with delayed healing and increase of stent thrombosis. The aim of our study was to evaluate the vascular time-related changes following implantation of a new SES coated with an amorphous silicon carbide that allows faster re-endothelisation (Orsiro-Biotronik). This prospective registry enrolled STEMI-patients with multi-vessel disease, thus candidates for a two-step procedure. PCI of the culprit lesion was performed with at least one Orsiro stent that was OCT-analysed during the second-step procedure (deferred to 30,90 and 180-days). 16 of the 95 patients with MVD underwent an OCT evaluation of the study device implanted in the culprit lesion during the second-step staged procedure and were enrolled in the present Registry. A total of 3060-struts were analysed. The percentage of uncovered struts was 19.6% at30-days, 1.3% at90-days and 1.8% at180-days (p<0.001). The percentage of cross section with ≥1 uncovered struts were 51.3% at30-days, 6.5% at90-days and 5.7% at180-days (p<0.001). The percentage of cross sections containing thrombus was 6.2% at30-days while no thrombus was detected both at90 and 180-days. Our data shows that the new Orsiro stent...Continue Reading

References

May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Mar 1, 2008·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jun TanigawaCarlo Di Mario
Jun 7, 2012·Circulation. Cardiovascular Interventions·Tullio PalmeriniGregg W Stone
Jan 29, 2013·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Tomohisa TadaAdnan Kastrati
Jan 31, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Alessandro LupiItalo Porto

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Citations

Mar 18, 2017·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Ran KornowskiAbid Assali
Mar 15, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Salvatore CasseseMichael Joner
Apr 14, 2018·Journal of Interventional Cardiology·Еvgeny KretovMartin W Bergmann
Oct 14, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jacek LegutkoDariusz Dudek
Jun 15, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Andreas BaumbachWilliam Wijns
Jun 15, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jose Maria de la Torre HernandezJavier Escaned
Apr 18, 2019·Journal of Cardiovascular Medicine·Antonio Luca BartorelliMaurizio Turturo
Sep 12, 2017·Expert Review of Medical Devices·Juan F IglesiasThomas Pilgrim

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