Time required to achieve maximum concentration of amikacin in synovial fluid of the distal interphalangeal joint after intravenous regional limb perfusion in horses

American Journal of Veterinary Research
Isabelle KilcoyneJ E Dechant

Abstract

OBJECTIVE To determine the maximum concentration (Cmax) of amikacin and time to Cmax (Tmax) in the distal interphalangeal (DIP) joint in horses after IV regional limb perfusion (IVRLP) by use of the cephalic vein. ANIMALS 9 adult horses. PROCEDURES Horses were sedated and restrained in a standing position and then subjected to IVRLP (2 g of amikacin sulfate diluted to 60 mL with saline [0.9% NaCl] solution) by use of the cephalic vein. A pneumatic tourniquet was placed 10 cm proximal to the accessory carpal bone. Perfusate was instilled with a peristaltic pump over a 3-minute period. Synovial fluid was collected from the DIP joint 5, 10, 15, 20, 25, and 30 minutes after IVRLP; the tourniquet was removed after the 20-minute sample was collected. Blood samples were collected from the jugular vein 5, 10, 15, 19, 21, 25, and 30 minutes after IVRLP. Amikacin was quantified with a fluorescence polarization immunoassay. Median Cmax of amikacin and Tmax in the DIP joint were determined. RESULTS 2 horses were excluded because an insufficient volume of synovial fluid was collected. Median Cmax for the DIP joint was 600 μg/mL (range, 37 to 2,420 μg/mL). Median Tmax for the DIP joint was 15 minutes. CONCLUSIONS AND CLINICAL RELEVANCE Tmax ...Continue Reading

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Citations

Feb 19, 2019·Veterinary Surgery : VS·Amanda H PlunkettTodd C Holbrook
Aug 18, 2020·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·Kajsa GustafssonGal Kelmer
Mar 3, 2021·Journal of Veterinary Pharmacology and Therapeutics·Heather K Knych, K Gary Magdesian
Mar 6, 2021·Journal of Equine Veterinary Science·Adriana F S GarciaGesiane Ribeiro
May 13, 2021·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·Kajsa GustafssonGal Kelmer
Jul 17, 2021·Veterinary Surgery : VS·Hannah E CooperKyla F Ortved

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