Time-resolved analysis of fMRI signal changes using Brain Activation Movies

Journal of Neuroscience Methods
Christian WindischbergerEwald Moser

Abstract

Conventional fMRI analyses assess the summary of temporal information in terms of the coefficients of temporal basis functions. Based on established finite impulse response (FIR) analysis methodology we show how spatiotemporal statistical parametric maps may be concatenated to form Brain Activation Movies (BAMs), dynamic activation maps representing the temporal evolution of brain activation throughout task performance. These BAMs enable comprehensive assessment of the dynamics in functional topology without restriction to predefined regions and without detailed information on the stimulus paradigm. We apply BAM visualization to two fMRI studies demonstrating the additional spatiotemporal information available compared to standard fMRI result presentation. Here we show that BAMs allow for unbiased data visualization providing dynamic activation maps without assumptions on the neural activity except reproducibility across trials. It may thus be useful in proceeding from static to dynamic brain mapping, widening the range of fMRI in neuroscience. In addition, BAMs might be helpful tools in visualizing the temporal evolution of activation in "real-time" for better and intuitive understanding of temporal processes in the human brain.

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Citations

Dec 17, 2009·Der Radiologe·C WindischbergerE Moser
Dec 25, 2009·Neuroinformatics·Martin PykaCarsten Konrad
Jul 27, 2012·Neuroscience Bulletin· WurinaShi-Gang Zhao
Apr 15, 2014·PloS One·Klaudius KalcherEwald Moser
Oct 25, 2011·Journal of Neuroscience Methods·Zhen-Xiang ZangYu-Feng Zang
Oct 22, 2010·Human Brain Mapping·César Caballero GaudesPenny A Gowland
Jan 19, 2010·NeuroImage·Marina López-SolàNarcís Cardoner
Dec 17, 2010·World Journal of Radiology·Ewald Moser
Jul 30, 2014·Frontiers in Neuroscience·Chien-Chung Chen

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