Time-resolved circular dichroism in carbonmonoxy-myoglobin: the central role of the proximal histidine

Chirality
Thibault Dartigalongue, François Hache

Abstract

A calculation of the circular dichroism (CD) spectra of carbonmonoxy- and deoxy-myoglobin is carried out in relation to a time-resolved CD experiment. This calculation allows us to assign a dominant role to the proximal histidine in the definition of the electronic normal modes and to interpret the transient CD structure observed in a strain of the proximal histidine. This strain builds up in 10 ps and relaxes in 50 ps as the protein evolves towards its deoxy form.

References

Jul 14, 1971·Journal of the American Chemical Society·M C Hsu, R W Woody
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M LimP A Anfinrud
Oct 8, 1999·Biophysical Journal·J VojtechovskýI Schlichting
Jun 21, 2003·Science·Friedrich SchottePhilip A Anfinrud
Dec 16, 2003·The Journal of Biological Chemistry·Takayuki InuzukaIsao Morishima

❮ Previous
Next ❯

Citations

Aug 12, 2010·Bioscience, Biotechnology, and Biochemistry·Yoshihiro OchiaiShugo Watabe
Mar 17, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Yoshihiro OchiaiShugo Watabe
Sep 22, 2006·Journal of Biochemistry·Nobuhiko Ueki, Yoshihiro Ochiai
Feb 19, 2019·Chemical Science·Jérémy R RouxelShaul Mukamel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.