Time-resolved microdialysis for in vivo neurochemical measurements and other applications

Annual Review of Analytical Chemistry
Kristin Schultz, Robert T Kennedy

Abstract

Monitoring changes in chemical concentrations over time in complex environments is typically performed using sensors and spectroscopic techniques. Another approach is to couple sampling methods, such as microdialysis, with chromatographic, electrophoretic, or enzymatic assays. Recent advances of such coupling have enabled improvements in temporal resolution, multianalyte capability, and automation. In a sampling and analysis method, the temporal resolution is set by the mass sensitivity of the analytical method, analysis time, and zone dispersion during sampling. Coupling methods with high speed and mass sensitivity to microdialysis sampling help to reduce some of these contributions to yield methods with temporal resolution of seconds. These advances have been primarily used in monitoring neurotransmitters in vivo. This review covers the problems associated with chemical monitoring in the brain, recent advances in using microdialysis for time-resolved in vivo measurements, sample applications, and other potential applications of the technology such as determining reaction kinetics and process monitoring.

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Citations

Jan 29, 2013·Applied Biochemistry and Biotechnology·Anish KhanSulaiman Ab Ghani
Jun 19, 2013·Annual Review of Analytical Chemistry·Michelle L Rogers, Martyn G Boutelle
Apr 26, 2013·ACS Chemical Neuroscience·Hongyan YangAnne M Andrews
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Methods Mentioned

BETA
microsensors
electrophoresis
chips
biosensor

Software Mentioned

LabView

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