Time response of carboplatin-induced nephrotoxicity in rats

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Kazim HusainL P Rybak

Abstract

Carboplatin, a second-generation platinum-containing anti-cancer drug, is currently being used against human cancers. High-dose carboplatin chemotherapy can cause renal tubular injury in cancer patients. We have shown a dose-dependent nephrotoxicity of carboplatin in a rat model. However, the time response of carboplatin-induced renal injury has not been explored. This study investigated the time response of carboplatin-induced nephrotoxicity in rat. Male Wistar rats (250-300 g) were divided into two groups of 30 animals each and treated as follows: (1) control (saline, intraperitoneally) and (2) carboplatin (256 mg kg(-1), intraperitoneally). The animals (n = 6) from each group were sacrificed 1-5 days after treatment. The blood and kidneys were isolated and analyzed. Plasma creatinine, blood urea nitrogen (BUN), and blood urea levels were increased significantly in response to carboplatin in a time-dependent manner, indicating potential nephrotoxicity. Carboplatin time-dependently increased the renal platinum concentration, renal xanthine oxidase activity, increased membrane lipid peroxidation (MDA) concentration, while ratio of reduced-to-oxidized glutathione (GSH/GSSG) depleted significantly, indicating oxidative renal inju...Continue Reading

Citations

Dec 24, 2013·Environmental Toxicology and Pharmacology·Ravi KhakhariyaS J Rajput
Aug 4, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mirian WatanabeMaria de Fátima Fernandes Vattimo
May 26, 2009·Joint, Bone, Spine : Revue Du Rhumatisme·Omer Faruk SendurMukadder Serter
Oct 26, 2007·American Journal of Physiology. Renal Physiology·Daisuke SonMasaomi Nangaku
Jun 18, 2009·Archives of Biochemistry and Biophysics·Daniela GiustariniRanieri Rossi

❮ Previous
Next ❯