Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease

ENeuro
Huei-Bin WangChristopher S Colwell

Abstract

Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction. Disturbances in sleep/wake cycles are common among HD patients with reports of delayed sleep onset, frequent bedtime awakenings, and fatigue during the day. The heterozygous Q175 mouse model of HD has been shown to phenocopy many HD core symptoms including circadian dysfunctions. Because circadian dysfunction manifests early in the disease in both patients and mouse models, we sought to determine if early intervention that improve circadian rhythmicity can benefit HD and delay disease progression. We determined the effects of time-restricted feeding (TRF) on the Q175 mouse model. At six months of age, the animals were divided into two groups: ad libitum (ad lib) and TRF. The TRF-treated Q175 mice were exposed to a 6-h feeding/18-h fasting regimen that was designed to be aligned with the middle of the time when mice are normally active. After three months of treatment (when mice reached the early disease stage), the TRF-treated Q175 mice showed improvements in their locomotor activity rhythm and sleep awakening time. Furthermore, we found improved heart rate variability (HR...Continue Reading

Citations

Aug 8, 2018·Journal of Biological Rhythms·Daniel S WhittakerChristopher S Colwell
Sep 1, 2018·Journal of Neuroscience Research·Dika KuljisChristopher S Colwell
Mar 25, 2019·Neurochemical Research·Christopher S Colwell, Cristina A Ghiani
Jul 31, 2019·Journal of Neuroscience Research·Benjamin SmarrChristopher S Colwell
Mar 17, 2019·EMBO Reports·Samuel Philip NobsEran Elinav
Mar 28, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Magali CabanasYoon H Cho
Oct 9, 2019·Journal of Huntington's Disease·Rachel Y CheongÅsa Petersén
Dec 15, 2018·The European Journal of Neuroscience·Sabra M AbbottPhyllis C Zee
Oct 18, 2019·Frontiers in Neuroscience·Tianfei HouZhenheng Guo
Jun 11, 2019·Annual Review of Nutrition·Amandine ChaixSatchidananda Panda
Jun 20, 2020·Critical Reviews in Food Science and Nutrition·Torsak TippairoteRodjana Chunhabundit
Jun 21, 2019·Nursing·Nancy L Urrutia
Jan 30, 2021·Current Obesity Reports·Maura FantiSebastian Brandhorst
Apr 24, 2021·Frontiers in Molecular Biosciences·Bethany CarterJoshua J Gamsby
Jul 3, 2021·Journal of Affective Disorders·Naís Lira SoaresJailane de Souza Aquino

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Methods Mentioned

BETA
RNA-seq
transgenic
dissection

Software Mentioned

Clocklab
IPA
NanoString
Ingenuity Pathways
SYSTAT
maze
SigmaPlot
ANY
Ingenuity
LabCorp

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