Time-Restricted Feeding Prevents Ablation of Diurnal Rhythms in Gastric Vagal Afferent Mechanosensitivity Observed in High-Fat Diet-Induced Obese Mice

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Stephen J KentishAmanda J Page

Abstract

Mechanosensitive gastric vagal afferents (GVAs) are involved in the regulation of food intake. GVAs exhibit diurnal rhythmicity in their response to food-related stimuli, allowing time of day-specific satiety signaling. This diurnal rhythmicity is ablated in high-fat-diet (HFD)-induced obesity. Time-restricted feeding (TRF) has a strong influence on peripheral clocks. This study aimed to determine whether diurnal patterns in GVA mechanosensitivity are entrained by TRF. Eight-week-old male C57BL/6 mice (N = 256) were fed a standard laboratory diet (SLD) or HFD for 12 weeks. After 4 weeks of diet acclimatization, the mice were fed either ad libitum or only during the light phase [Zeitgeber time (ZT) 0-12] or dark phase (ZT12-24) for 8 weeks. A subgroup of mice from all conditions (n = 8/condition) were placed in metabolic cages. After 12 weeks, ex vivo GVA recordings were taken at 3 h intervals starting at ZT0. HFD mice gained more weight than SLD mice. TRF did not affect weight gain in the SLD mice, but decreased weight gain in the HFD mice regardless of the TRF period. In SLD mice, diurnal rhythms in food intake were inversely associated with diurnal rhythmicity of GVA mechanosensitivity. These diurnal rhythms were entrained by...Continue Reading

Citations

Sep 12, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Stephen J KentishAmanda J Page
Nov 19, 2019·Minerva endocrinologica·Michael DoulberisJannis Kountouras
Nov 13, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Kirsteen N Browning, R Alberto Travagli
Jan 1, 2019·International Journal of Smart and Nano Materials·Timothy J EsworthyLijie Grace Zhang
Jun 11, 2019·Annual Review of Nutrition·Amandine ChaixSatchidananda Panda
Sep 24, 2021·The Journal of Physiology·Amanda J Page
Sep 23, 2021·Endocrine Reviews·Emily N ManoogianSatchidananda Panda

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