Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

Cell Metabolism
Amandine ChaixSatchidananda Panda

Abstract

Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the idea that a molecular clock is necessary for metabolic homeostasis. However, these mice often lack a normal feeding-fasting cycle. We tested whether time-restricted feeding (TRF) could prevent obesity and metabolic syndrome in whole-body Cry1;Cry2 and in liver-specific Bmal1 and Rev-erbα/β knockout mice. When provided access to food ad libitum, these mice rapidly gained weight and showed genotype-specific metabolic defects. However, when fed the same diet under TRF (food access restricted to 10 hr during the dark phase) they were protected from excessive weight gain and metabolic diseases. Transcriptome and metabolome analyses showed that TRF reduced the accumulation of hepatic lipids and enhanced cellular defenses against metabolic stress. These results suggest that the circadian clock maintains metabolic homeostasis by sustaining daily rhythms in feeding and fasting and by maintaining balance between nutrient and cellular stress responses.

Citations

Sep 16, 2018·Nature Reviews. Endocrinology·Claire Greenhill
Nov 12, 2018·Journal of Neuroendocrinology·Isa KolbeHenrik Oster
Mar 29, 2019·Chronobiology International·Shumin SunHiroaki Oda
Apr 3, 2019·International Journal of Molecular Sciences·Eleonore Maury
Jun 21, 2019·Nature Reviews. Endocrinology·Amandine Chaix, Satchidananda Panda
Apr 30, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Daniel Mauvoisin
Dec 7, 2019·Reviews in Endocrine & Metabolic Disorders·Marianna PellegriniSimona Bo
Mar 22, 2020·The Journal of Physiology·Therese FreireSamantha M Solon-Biet
May 20, 2020·Nature Reviews. Endocrinology·Víctor M Navarro
May 12, 2020·Endocrine Reviews·Yong Hoon Kim, Mitchell A Lazar
Jul 13, 2020·The FEBS Journal·Jacqueline KadingBrian J DeBosch
Jul 14, 2020·Journal of Pineal Research·Yuying LiJie Yin
Aug 13, 2020·Proceedings. Biological Sciences·Aidan J O'DonnellSarah E Reece
Mar 12, 2020·Current Pharmaceutical Design·Mariano Ruiz-Gayo, Nuria D Olmo
Sep 24, 2020·Journal of Biological Rhythms·Benjamin A Unruh, Shihoko Kojima
May 11, 2019·Nature Reviews. Endocrinology·Etienne Challet
Sep 19, 2019·Molecular Nutrition & Food Research·Lifeng GuiZhiguo Liu
Sep 11, 2019·American Journal of Physiology. Endocrinology and Metabolism·Mara A DedualDaniel Konrad
May 28, 2020·American Journal of Human Biology : the Official Journal of the Human Biology Council·Mariko UedaTetsuya Mizoue
May 16, 2020·Science·Filipa Rijo-FerreiraJoseph S Takahashi
Sep 27, 2019·Frontiers in Cell and Developmental Biology·Akshay BarejaJames P White
Jun 30, 2019·Current Diabetes Reports·Sangeeta Dhawan, Rama Natarajan
May 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Pieterjan DierickxMitchell A Lazar
Nov 7, 2019·Current Diabetes Reports·Juleen R Zierath
Sep 5, 2019·The Journal of Biological Chemistry·Shumin SunHiroaki Oda
Apr 8, 2020·Cells·Kristin Eckel-MahanMikhail G Kolonin
Jul 15, 2020·Critical Reviews in Food Science and Nutrition·Jéssica do Nascimento QueirozAlvaro Reischak-Oliveira
Jun 11, 2019·Annual Review of Nutrition·Amandine ChaixSatchidananda Panda
Dec 19, 2019·Chronobiology International·R B SinghO A Al-Bawareed

❮ Previous
Next ❯

Related Concepts