Time-Series Analysis of Tumorigenesis in a Murine Skin Carcinogenesis Model

Scientific Reports
Yoshimasa AotoYasubumi Sakakibara

Abstract

Recent years have witnessed substantial progress in understanding tumor heterogeneity and the process of tumor progression; however, the entire process of the transition of tumors from a benign to metastatic state remains poorly understood. In the present study, we performed a prospective cancer genome-sequencing analysis by employing an experimental carcinogenesis mouse model of squamous cell carcinoma to systematically understand the evolutionary process of tumors. We surgically collected a part of a lesion of each tumor and followed the progression of these tumors in vivo over time. Comparative time-series analysis of the genomes of tumors with different fates, i.e., those that eventually metastasized and regressed, suggested that these tumors acquired and inherited different mutations. These findings suggest that despite the occurrence of an intra-tumor selection event for malignant alteration during the transformation from early- to late-stage papilloma, the fate determination of tumors might be determined at an even earlier stage.

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K BrownA Balmain
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·J G EinspahrG T Bowden
Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Jul 10, 2003·Trends in Genetics : TIG·Eli Eisenberg, Erez Y Levanon
Mar 3, 2004·Nature Reviews. Cancer·P Andrew FutrealMichael R Stratton
Mar 17, 2004·Journal of Cell Science·Jason S RawlingsDouglas A Harrison
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jan 20, 2012·Nature·Mel Greaves, Carlo C Maley
Mar 9, 2012·The New England Journal of Medicine·Marco GerlingerCharles Swanton
Apr 17, 2012·Cell·Mathieu Laplante, David M Sabatini
Sep 25, 2012·Cancer Research·Charles Swanton
Dec 26, 2012·Archives of Toxicology·Michael SchwarzAlbert Braeuning
Feb 12, 2013·Nature Biotechnology·Kristian CibulskisGad Getz
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Sep 21, 2013·Nature·Rebecca A BurrellCharles Swanton
Apr 4, 2014·Bioinformatics·Anthony M BolgerBjoern Usadel
Sep 4, 2014·Cold Spring Harbor Perspectives in Medicine·Phillips Y Huang, Allan Balmain
Oct 11, 2014·The Journal of Investigative Dermatology·Allan Balmain, Stuart H Yuspa
Dec 20, 2014·Scientific Reports·Paul K NewtonPeter Kuhn
Jan 15, 2015·Cancer Cell·Nicholas McGranahan, Charles Swanton
Apr 17, 2015·Science Translational Medicine·Nicholas McGranahanCharles Swanton
Sep 26, 2015·Science·Iñigo Martincorena, Peter J Campbell
Nov 13, 2015·The New England Journal of Medicine·A Hunter ShainBoris C Bastian
Jan 19, 2016·Nature Genetics·Marc J WilliamsAndrea Sottoriva
Feb 18, 2016·Genes & Development·Theodoros KantidakisJesper Q Svejstrup
Dec 3, 2016·Nucleic Acids Research·Simon A ForbesPeter J Campbell
Jan 17, 2017·Nature Genetics·Alvin P Makohon-MooreChristine A Iacobuzio-Donahue
Feb 12, 2017·Cell·Nicholas McGranahan, Charles Swanton
Apr 27, 2017·The New England Journal of Medicine·Mariam Jamal-HanjaniUNKNOWN TRACERx Consortium
Nov 11, 2017·Nature Communications·Hyun-Tae ShinWoong-Yang Park

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Citations

May 1, 2021·Frontiers in Artificial Intelligence·Anuraag BukkuriIsabel K Darcy
Mar 30, 2021·Experimental Animals·Kazuhiro OkumuraYuichi Wakabayashi

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Methods Mentioned

BETA
deubiquitination

Software Mentioned

Genome Analysis Toolkit ( GATK )
LoFreq
FASTX
picard
samtools
GATK
Strelka
BWA
Trimmomatic
MuTect2

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