Time to blood culture positivity in Staphylococcus aureus bacteraemia to determine risk of infective endocarditis.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Fredrik KahnMagnus Rasmussen

Abstract

Patients with Staphylococcus aureus bacteraemia (SAB) at risk for infective endocarditis (IE) need to be identified because they should undergo echocardiography. We validated previous scoring systems for IE risk determination and evaluated whether time to blood culture positivity (TTP) could improve scoring systems. This retrospective population-based study included adults with SAB in 2016 in a derivation cohort and those from 2017 in a validation cohort. TTP was compared between patients with and without IE. A new score including TTP was constructed using a least absolute shrinkage selection operator. The new POSITIVE score was compared to the previously described PREDICT and VIRSTA scores. A total of 465 episodes with SAB were included in the derivation cohort, of which 38 (8.2%) represented IE. Median (interquartile range) TTP was significantly shorter in episodes with IE, at 8.7 (7.7-10.6) hours compared to those without, at 13.3 (10.5-16.5) hours. When using a cutoff at 13 hours, TTP had a sensitivity of 100% (95% confidence interval (CI), 91-100) and specificity of 52% (95% CI, 47-57) for IE. The POSITIVE score included TTP, intravenous drug use, embolizations and presence of preexisting heart conditions. It had a sensiti...Continue Reading

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Citations

Mar 10, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Karl OldbergMagnus Rasmussen
Feb 27, 2021·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Madiha FidaM Rizwan Sohail
May 12, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juan Sebastián Peinado-AcevedoFabián Jaimes
May 12, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Magnus RasmussenFredrik Kahn
May 12, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stamatis KarakonstantisDiamantis Kofteridis
Oct 17, 2021·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·David KrusMagnus Rasmussen

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