Time to consider ACE insertion/deletion genotypes and individual renoprotective treatment in diabetic nephropathy?

Kidney International
P JacobsenH H Parving

Abstract

One reason for the inadequacy of current renoprotective therapy and the persistent poor renal prognosis in diabetic nephropathy is the large interindividual variation in response to treatment. Genetic as well as non-genetic factors are known to influence treatment efficacy. This Commentary summarizes the impact of the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism in the ACE gene on initiation and progression of diabetic nephropathy.

References

Mar 26, 2002·Journal of the American Society of Nephrology : JASN·Frank G H van der KleijGerjan Navis
Feb 7, 2003·The New England Journal of Medicine·William E Evans, Howard L McLeod
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Peter JacobsenHans-Henrik Parving
Oct 2, 2004·Kidney International·Kasper RossingHans-Henrik Parving
Aug 10, 2005·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Peter Karl Jacobsen

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Citations

Jan 18, 2008·Journal of the American Society of Nephrology : JASN·Hans-Henrik ParvingBarry M Brenner
Jan 26, 2011·Annual Review of Pathology·Yashpal S KanwarSheldon Chen
Jun 23, 2009·Transplantation Reviews·Abdallah S GearaReza Abdi
Sep 22, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·D CurrieUNKNOWN UK Warren 3/GoKinD Study Group
Nov 3, 2009·The Journal of Pathology·Amy J McKnightAlexander P Maxwell
Dec 9, 2009·Clinical and Experimental Immunology·G ZazaF P Schena
Jun 16, 2015·Frontiers in Endocrinology·Ini-Isabée WitzelHabiba Alsafar
Sep 6, 2006·Hypertension·Sara GiuntiMark E Cooper
Dec 25, 2007·Experimental Biology and Medicine·Yashpal S KanwarFarhad R Danesh

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