Time to diagnosis in young-onset dementia and its determinants: the INSPIRED study

International Journal of Geriatric Psychiatry
Brian DraperAdrienne Withall

Abstract

The objective of this study is to identify factors determining the time to diagnosis for young-onset dementia (YOD), defined as dementia with symptom onset before age 65 years, by mapping the diagnostic pathways. Participants were recruited via healthcare professionals, community support organisations or were self-referred. Information was obtained by interviews with the person with YOD and their carer, and medical record reviews. Clinical dementia diagnoses were independently ratified by consensus review. Participants included 88 people with YOD (mean age of onset = 55.4 years), due to Alzheimer's disease (AD) (53.4%, n = 47), frontotemporal dementia (FTD) (15.9%, n = 14) and other causes (30.7%, n = 27). Median time from symptom onset to first consultation was 2.3 years, to dementia diagnosis 3.2 years, to family awareness of dementia diagnosis 3.5 years and to final diagnosis of the type of dementia 4.7 years. Non-dementia diagnoses occurred in 48.9%, including depression (30.7%) and mild cognitive impairment (MCI) (17.0%). Participants with younger age of onset had significantly longer time to first consultation and family awareness of the dementia diagnosis. The time to dementia diagnosis was significantly longer when the ...Continue Reading

References

Jul 11, 1998·International Journal of Geriatric Psychiatry·G LuscombeS Freeth
Jun 25, 2004·American Journal of Alzheimer's Disease and Other Dementias·Charles DrebingLawrence Herz
May 31, 2007·American Journal of Alzheimer's Disease and Other Dementias·Peter K Panegyres, Kate Frencham
Nov 4, 2008·The Medical Journal of Australia·Catherine M SpeechlyErin Passmore
Jan 14, 2010·International Journal of Geriatric Psychiatry·Tor Atle RosnessKnut Engedal
Jul 24, 2010·Lancet Neurology·Martin N RossorJason D Warren
Aug 26, 2010·International Psychogeriatrics·Emma SvanbergJoshua Stott
Jun 10, 2011·The New England Journal of Medicine·Ronald C Petersen
Jul 7, 2011·International Psychogeriatrics·Deliane van VlietFrans R J Verhey
May 30, 2012·Psychological Medicine·D van VlietF R J Verhey
Oct 3, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Claudia CooperGill Livingston
Dec 18, 2013·International Psychogeriatrics·Winnie QianCorinne E Fischer
Dec 29, 2013·International Journal of Epidemiology·William S KremenMichael J Lyons
Oct 14, 2014·International Psychogeriatrics·Adrienne WithallHenry Brodaty

❮ Previous
Next ❯

Citations

Jul 14, 2016·Internal Medicine Journal·B Draper, A Withall
Jul 28, 2016·Journal of Molecular Neuroscience : MN·Christina J Perry
Apr 5, 2018·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Dhamidhu EratneJeffrey Cl Looi
Apr 26, 2018·Dementia and Geriatric Cognitive Disorders·Lara HvidstenHege Kersten
Aug 21, 2018·Dementia·Andrea M MayrhoferMichael Walker
Aug 4, 2018·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Konstantina G YiannopoulouSokratis G Papageorgiou
Dec 7, 2018·Current Opinion in Psychiatry·Monica CationsBrian Draper
Feb 15, 2019·Applied Neuropsychology. Adult·Paola GuarigliaLaura Piccardi
Apr 3, 2019·American Journal of Alzheimer's Disease and Other Dementias·Sarah BaillonLatha Velayudhan
Aug 23, 2019·Journal of Psychosocial Nursing and Mental Health Services·Caroline KiltyÁine de Róiste
Nov 26, 2019·International Psychogeriatrics·Christopher M BlackRezaul K Khandker
Jan 31, 2020·Health & Social Care in the Community·Robert J Hagan
Feb 1, 2020·Brain : a Journal of Neurology·Charles R Marshall, Jason D Warren
May 14, 2020·The Journal of Neuropsychiatry and Clinical Neurosciences·Samantha M LoiDennis Velakoulis
May 16, 2020·Neurocase·James R BurrellJohn R Hodges
Jun 3, 2020·International Psychogeriatrics·Clarissa GiebelAravind Komuravelli
Aug 29, 2020·International Psychogeriatrics·Samantha M LoiDennis Velakoulis
Sep 7, 2020·International Journal of Geriatric Psychiatry·Samantha M LoiDennis Velakoulis
Sep 12, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Annalisa ChiariMarco Vinceti
Dec 12, 2018·Journal of Alzheimer's Disease : JAD·Lara HvidstenHege Kersten
Oct 28, 2019·Aging & Mental Health·Mary O'MalleyJacqueline Parkes
Nov 30, 2019·British Journal of Nursing : BJN·Caroline KiltyAine de Roiste
Sep 30, 2020·Medicina·Sophia X Sui, Julie A Pasco
Apr 5, 2018·Journal of Alzheimer's Disease : JAD·Monica CationsAdrienne Withall
May 29, 2019·Alzheimer Disease and Associated Disorders·Christopher M BlackRezaul K Khandker
Jul 3, 2019·International Journal of Alzheimer's Disease·Davneet JudgeChristopher M Black
Sep 19, 2019·BJPsych Open·Mary O'MalleyJanet Carter
Feb 6, 2021·Journal of Multidisciplinary Healthcare·Kirsten Thorsen, Aud Johannessen
Jan 2, 2021·International Journal of Molecular Sciences·Sophia X SuiJulie A Pasco
Feb 3, 2021·BMJ Open·Monica CationsMaria Inacio
Feb 25, 2021·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Samantha M LoiDennis Velakoulis
May 14, 2021·The Australian and New Zealand Journal of Psychiatry·Monica CationsBrian Draper
Jun 16, 2021·International Psychogeriatrics·Clarissa Giebel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.