Time to dP/dtmax reflects both inotropic and chronotropic properties of cardiac contraction: a conscious dog study

Physiological Measurement
D AdlerE L Yellin

Abstract

This study supports a mathematical model and previous findings indicating that td, the time from onset of contraction to dP/dtmax, reflects the time-dependent aspects of contraction and hence decreases with increasing contractility. Combined data from 20 conscious instrumented dogs create a highly significant inverse and linear td-HR (heart rate) relation. Both norepinephrine and isoproterenol decreased td values, but norepinephrine, in contrast to isoproterenol, decreased the heart rate by a reflex response. Despite the remarkable decline in heart rate (25.8%) td was decreased (16.5%). During wide spontaneous R-R variations longer preceding intervals gave shorter td values. The latter two facts indicate the dependence of td on the contractile state rather than it being merely interval dependent.

References

Mar 21, 1985·Journal of Theoretical Biology·D AdlerG A Klassen
Apr 1, 1969·The American Journal of Cardiology·E H SonnenblickC W Urschel
Mar 1, 1983·Basic Research in Cardiology·J M CapassoE H Sonnenblick
Jan 1, 1964·Cardiologia : bollettino della Società italiana di cardiologia·J H SIEGELW S WILSON

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Citations

Jun 1, 1996·Current Opinion in Neurobiology·E A Jonas, L K Kaczmarek
Oct 23, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Marty D SprangerDonal S O'Leary

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