Jun 30, 2006

Time to give the first medication during resuscitation in out-of-hospital cardiac arrest

Jon C RittenbergerJ J Menegazzi


There is no evidence showing an impact from any advanced cardiac life support (ACLS) medications on patient survival following cardiac arrest. One potential reason for a lack of such benefit may be medication timing. We formed the hypothesis that medications are given late after rescuer arrival, limiting any benefit. We performed a meta-analysis to determine the time from emergency medical services (EMS) dispatch to first medication administration, regardless of route, during out-of-hospital cardiac arrest (OOHCA). Then, the mean time and ranges of reported study medication delivery in clinical trials where medication was the experimental intervention was determined. We conducted a comprehensive literature review between January 1990 and August 2005 in MEDLINE using the following MeSH headings: cardiopulmonary resuscitation, cardiac arrest, heart arrest, EMS, EMT, ambulance, and the names of all ACLS medications. We reviewed the abstracts of 632 studies and full manuscripts of 248 published papers. We eliminated the following articles from further analysis: non-peer reviewed; all without human primary data (includes review articles, guidelines or consensus manuscripts, editorials, or simulation studies); animal data; case repor...Continue Reading

  • References41
  • Citations22


  • References41
  • Citations22


Mentioned in this Paper

Acrocallosal Syndrome
Meta-Analysis (Publications)
Blood Vessel
Antidiuretic Hormone Measurement
Sleep Disorders, Circadian Rhythm
GLI3 gene
Epinephrine Measurement

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